Lithium Induced Toxicity in Rats: Blood Serum Chemistry, Antioxidative Enzymes in Red Blood Cells and Histopathological Studies

スポンサーリンク

概要

• 論文の詳細を見る

• Lithium is commonly used in treating mental disorders and bipolar diseases. As physicians frequently keep the patients on long-term lithium therapy, awareness of the numerous side effects and pathogenesis of this lightest alkali metal is needed for such treatments. The present study was designed to evaluate the toxic effect of small doses of lithium chloride in male Wistar rats. The oral administration of lithium chloride (15, 30 mg/kg body wt) for 7 weeks through their drinking water elicited a significant alteration in their body weight and blood serum chemistry. The serum enzyme levels of alkaline phosphatase (ALP), high density lipoprotein (HDLP), and creatinine kinase (CK) were diminished, whereas the level of serum urea and glucose were elevated in the lithium treated animals, depicting the disturbed general physiological status. Furthermore, a marked inhibition in the levels of serum alanine and aspartate transaminases (ALT and AST) reflected a stimulating transamination reaction in hepatic and renal tissues. Lithium exposure also reduced the glutathione (GSH) level and stimulated the lipid peroxidation (LPO) level in the rat blood cells, indicating oxidative stress in the red blood cells due to lithium exposures. The histopathological observations of the liver and kidney tissues revealed many deformities and histological alterations due to lithium treatment. The results of present study suggest that small doses of lithium induce toxicity in rat blood as well as in liver and kidney tissues. However, the precise mechanism of lithium toxicity is still incompletely understood.

著者

• Ahmad Mohammad

  Department of Applied Medical Sciences, Community College, King Saud University

• Elnakady Yasser

  Department of Zoology, College of Science, King Saud University

• Farooq Muhammad

  Department of Zoology, College of Science, King Saud University

• Wadaan Muhammad

  Department of Zoology, College of Science, King Saud University

• Farooq Muhammad

  Department Of Applied Physics Of Engineering Nagoya University

• Farooq Muhammad

  Department Of Agronomy University Of Agriculture

関連論文

• Lithium Induced Toxicity in Rats: Blood Serum Chemistry, Antioxidative Enzymes in Red Blood Cells and Histopathological Studies
• The Hydrodynamic Interaction of Two Spheres in a Viscous Fluid at Small Non-Zero Reynolds Number : Axisymmetric Case
• Analysis of the Steady Navier-Stokes Equations Based on Green's Function Approach
• Analysis of the Unsteady Navier-Stokes Equations Based on Green's Function Approach
• Enhancing the Performance of Direct Seeded Fine Rice by Seed Priming(Agronomy)
• Mulberry leaf water extract inhibits bermudagrass and promotes wheat growth
• Comparison of conventional puddling and dry tillage in rice-wheat system
• Enhancing the performance of transplanted coarse rice by seed priming
• Comparative efficacy of surface drying and re-drying seed priming in rice : changes in emergence, seedling growth and associated metabolic events

スポンサーリンク