Progression of Glomerulonephritis to End-Stage Kidney Disease in a Cat with Nephrotic Syndrome
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概要
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A percutaneous renal biopsy was performed on a 3-year-old female Japanese domestic cat with pleural effusion, mild azotemia, hypoalbuminemia, hypercholesterolemia, and proteinuria. Glomerular lesions included mild diffuse hypercellularity and numerous capsular adhesions with segmental sclerosis/hyalinosis of glomerular tufts. Electron microscopy revealed many subendothelial dense deposits with characteristic outer protrusion of glomerular basement membrane. Diffuse and global granular deposits of IgG and C3 were detected along the capillary walls. Tubulo-interstitial changes were mild at the time of biopsy, but progression of the disease was predicted because of the many capsular adhesions of the glomerular tufts. The cat was fed a prescription diet without any other specific or symptomatic therapy after renal biopsy, and died 43 weeks after the biopsy. At necropsy, extensive tubulo-interstitial fibrosis and mononuclear cell infiltration had developed throughout the cortex and outer medulla, and most glomeruli had extensive global sclerosis or obsolescence with less prominent depositions of IgG and C3.
論文 | ランダム
- 咽頭炎,扁桃炎,気管支炎 (小児の治療指針) -- (呼吸器)
- 予期せぬ舌扁桃肥大に対し挿管用ラリンジアルマスクを用いたファイバー挿管法が有効であった病的肥満患者の麻酔経験
- 咽頭痛 (初診外来における初期診療)
- 小児の口腔・耳鼻科領域の漢方 (特集 小児の漢方療法--エキス剤を使いこなそう)
- IgA腎症における扁桃摘出術の効果と課題 (AYUMI IgA腎症--最新動向)