Sibutramine and L-Carnitine Compared to Sibutramine Alone on Insulin Resistance in Diabetic Patients
スポンサーリンク
概要
- 論文の詳細を見る
Objective To evaluate the effects of one year of treatment with sibutramine plus L-carnitine compared to sibutramine on body weight, glycemic control, and insulin resistance state in type 2 diabetic patients. Methods Two hundred and fifty-four patients with uncontrolled type 2 diabetes mellitus (T2DM) [glycated hemoglobin (HbA1c) >8.0%] in therapy with different oral hypoglycemic agents or insulin were enrolled in this study and randomised to take sibutramine 10 mg plus L-carnitine 2 g or sibutramine 10 mg in monotherapy. We evaluated at baseline, and after 3, 6, 9, and 12 months these parameters: body weight, body mass index (BMI), glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), post-prandial plasma glucose (PPG), fasting plasma insulin (FPI), homeostasis model assessment insulin resistance index (HOMA-IR), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), triglycerides (Tg), retinol binding protein-4 (RBP-4), resistin, visfatin, high sensitivity-C reactive protein (Hs-CRP). Results There was a decrease in body weight, BMI, HbA1c, FPI, HOMA-IR, and RBP-4 in both groups, even when the values obtained with sibutramine plus L-carnitine were lower than the values obtained in sibutramine group. There was a faster decrease of FPG, PPG, TC, LDL-C, resistin and Hs-CRP with sibutramine plus L-carnitine even when no differences between the two groups were obtained. Furthermore, only sibutramine plus L-carnitine improved Tg, and visfatin. Conclusion Sibutramine plus L-carnitine gave a faster improvement of lipid profile, insulin resistance parameters, glycemic control, and body weight compared to sibutramine.
著者
-
DEROSA Giuseppe
Department of Internal Medicine and Therapeutics, University of Pavia
-
MAFFIOLI Pamela
Department of Internal Medicine and Therapeutics, University of Pavia
-
AT SALVADEO
Department of Internal Medicine and Therapeutics, University of Pavia
-
FERRARI Ilaria
Department of Internal Medicine and Therapeutics, University of Pavia
-
Ferrari Ilaria
Department Of Internal Medicine And Therapeutics University Of Pavia
-
Mereu Roberto
Department Of Internal Medicine And Therapeutics University Of Pavia
-
Palumbo Ilaria
Department Of Internal Medicine And Therapeutics University Of Pavia
-
Gravina Alessia
Department Of Internal Medicine And Therapeutics University Of Pavia
-
Derosa Giuseppe
Department Of Internal Medicine And Therapeutics Centro Ipertensione E Fisiopatologia Cardiovascolar
-
RANDAZZO SABRINA
Department of Internal Medicine and Therapeutics, University of Pavia
-
Randazzo Sabrina
Department Of Internal Medicine And Therapeutics University Of Pavia Fondazione Irccs Policlinico S
-
Maffioli Pamela
Department Of Internal Medicine And Therapeutics Centro Ipertensione E Fisiopatologia Cardiovascolare University Of Pavia
-
FG Cicero
"G. Descovich" Atherosclerosis Study Center, Department of Internal Medicine, Aging and Kidney Diseases, University of Bologna
-
FG Cicero
"G. Descovich" Atherosclerosis Study Center, Department of Internal Medicine, Aging and Kidney Diseases, University of Bologna
関連論文
- Pioglitazone Metabolic Effect in Metformin-Intolerant Obese Patients Treated with Sibutramine
- Candesartan effect on inflammation in hypertension
- Effects of Insulin Therapy with Continuous Subcutaneous Insulin Infusion (CSII) in Diabetic Patients : Comparison with Multi-daily Insulin Injections Therapy (MDI)
- Effect of body weight loss and normalization on blood pressure in overweight non-obese patients with stage 1 hypertension
- Blood Pressure Control and Inflammatory Markers in Type 2 Diabetic Patients Treated with Pioglitazone or Rosiglitazone and Metformin
- Telmisartan and Irbesartan Therapy in Type 2 Diabetic Patients Treated with Rosiglitazone : Effects on Insulin-Resistance, Leptin and Tumor Necrosis Factor-α
- Thiazolidinedione Effects on Blood Pressure in Diabetic Patients with Metabolic Syndrome Treated with Glimepiride
- Effects of Manidipine/Delapril versus Olmesartan/Hydrochlorothiazide Combination Therapy in Elderly Hypertensive Patients with Type 2 Diabetes Mellitus
- Comparison of the Effects of Valsartan and Felodipine on Plasma Leptin and Insulin Sensitivity in Hypertensive Obese Patients
- Effects of Telmisartan Compared with Eprosartan on Blood Pressure Control, Glucose Metabolism and Lipid Profile in Hypertensive, Type 2 Diabetic Patients : a Randomized, Double-Blind, Placebo-Controlled 12-Month Study
- Sibutramine and L-Carnitine Compared to Sibutramine Alone on Insulin Resistance in Diabetic Patients
- Different actions of losartan and ramipril on adipose tissue activity and vascular remodeling biomarkers in hypertensive patients
- Differential effects of candesartan and olmesartan on adipose tissue activity biomarkers in type II diabetic hypertensive patients
- Effect of Delapril/Manidipine vs Olmesartan/ Hydrochlorothiazide Combination on Insulin Sensitivity and Fibrinogen in Obese Hypertensive Patients
- Effects of Nateglinide and Glibenclamide on Prothrombotic Factors in Naïve Type 2 Diabetic Patients Treated with Metformin: A 1-Year, Double-Blind, Randomized Clinical Trial
- Orlistat and L-carnitine compared to orlistat alone on insulin resistance in obese diabetic patients
- Role of angiotensin II in plasma PAI-1 changes induced by imidapril or candesartan in hypertensive patients with metabolic syndrome
- Glyco-metabolic profile among type 2 diabetic patients with erectile dysfunction
- Effect of Valsartan Addition to Amlodipine on Insulin Sensitivity in Overweight-Obese Hypertensive Patients
- Fibrinolysis and insulin sensitivity in imidapril and candesartan (FISIC study) recipients with hypertension