癌焼灼治療を目的としたCo添加Fe3O4粒子分散体の交流磁場印加による昇温特性の評価

概要

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We developed cobalt-containing Fe3O4 particles, (Co, Fe)3O4, whose particle sizes and magnetic properties were precisely controlled to apply hysteresis-loss heating materials in thermoablation. The crcivity of the (Co, Fe)3O4 particles was adjusted in the range of 19.1 to 42.1 kA/m by changing the content of Co, while the particle size was maintained about 20nm. SiO2-coated (Co, Fe)3O4 particles were dispersed in water. The temperature increase characteristics were examined for the dispersant containing (Co, Fe)3O4 particles with the crcivity of 24.0kA/m by applying a 120kHz ac magnetic field with an amplitude up to 50.1kA/m. The temperature increase ΔT/Δt was proportional to the amplitude of magnetic field, but was not saturated even when a magnetic field of 50.1kA/m was applied. The specific loss power (SLP) calculated from the ΔT/Δt and the particle content of the dispersant did not show a clear dependence on the coercivity, but a maximum value of over 1000W/g was obtained for a dispersant containing (Co, Fe)3O4 particles with a coercivity of 24.0kA/m under an ac magnetic field of 50.1kA/m.