Re-evaluation of Protease Activity of Reelin

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概要

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• Reelin is a very large secreted glycoprotein that is essential for brain formation and function, but the mechanism by which it affects the dynamics and morphology of neuronal cells remains unsolved. One previous study claimed that Reelin has a proteolytic activity against extracellular matrix proteins, which might explain many of the actions of Reelin. Therefore, in this study wild-type Reelin protein and its mutant in which a supposedly critical serine residue was replaced were expressed and tested for their self-degrading and laminin-degrading activities. We found that both of these proteins generated totally the same cleaved fragments and that neither of them is capable of degrading laminin. It is thus likely that Reelin is not a serine protease and is unable to degrade extracellular matrix.

• 公益社団法人　日本薬学会の論文

著者

• Hattori Mitsuharu

  Department Of Biomedical Science Graduate School Of Pharmaceutical Sciences Nagoya City University

• Kohno Takao

  Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University

関連論文

• Reelin, radial fibers and cortical evolution : Insights from comparative analysis of the mammalian and avian telencephalon
• Regulated cleavage of a contact-mediated axon repellent, ephrin-A2
• Re-evaluation of Protease Activity of Reelin

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