完全長ｃＤＮＡとゲノム医科学

概要

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As the result of the human genome project, the entire sequence of human genome was determined. Unfortunately, it is still not a trivial task to identify genes from these genome sequences only by the computational methods. Thus, full-length cDNAs are indispensable for the identification of genes and the determination of their structures. In addition, cDNAs will be a valuable resource for the functional analysis of the gene. We have performed so called FLJ project of collecting and determining the entire sequences of putative full-length cDNA clones. In this project, we extensively used cDNA libraries made by oligo-capping method. In this review, I will describe the current status of FLJ project and high-through-put functional analysis using full-length cDNA clones obtained by FLJ project.
日本炎症・再生医学会の論文