The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction: Pathophysiology and Pharmacotherapy of Overactive Bladder

スポンサーリンク

概要

• 論文の詳細を見る

• Overactive bladder (OAB) syndrome, which is characterized by a complex of storage symptoms (urinary urgency, frequency, nocturia, and urgency incontinence) is highly prevalent within the general population, causing major distress to patients in terms of their psychosocial and physical functioning. Muscarinic receptors of bladder smooth muscles are involved in both normal and disturbed bladder contraction. The muscarinic receptor functions may change in bladder disorders associated with OAB, implying that mechanisms, which normally have little clinical importance, may be up-regulated and contribute to the pathophysiology of OAB. In addition, several reports have suggested that various stimulations release many substances, including adenosine triphosphate, prostaglandins, nitric oxide, and acetylcholine, from bladder urothelium, which contribute to pathophysiology of the increased bladder sensation, OAB symptoms, and detrusor overactivity. Bladder urothelium possesses a non-neuronal cholinergic system and high density of muscarinic receptors. The roles and functions of the non-neuronal cholinergic system in OAB are now being evaluated. In the pharmacotherapy of OAB, antimuscarinic agents are the first choice drugs. Furthermore, new therapeutic targets at the levels of the urothelium, detrusor muscles, autonomic and afferent pathways, spinal cord, and brain are proposed. In this review, the pathophysiology of OAB, especially the role of non-neuronal acetylcholine, is discussed. In addition, new drugs with new action mechanisms will be introduced.

著者

• NAGATA Takashi

  Department of Physics, Aoyama-Gakuin University

• HOMMA YUKIO

  Department of Urology, University of Tokyo

• Yoshida Masaki

  Department of Urology, Kumamoto Hospital of Japan Labor Health and Welfare Organization, Japan

• Masunaga Koichi

  Department of Urology, Tokyo Metropolitan Geriatric Hospital, Japan

• Yono Makoto

  Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Japan

• Homma Yukio

  Department Of Urology Faculty Of Medicine The University Of Tokyo

• Masunaga Koichi

  Department Of Urology Graduate School Of Medical Sciences Kumamoto University

• Nagata Takashi

  Department Of Earth And Space Science Graduate School Of Science Osaka University

• Yoshida Masaki

  Department Of 2nd Internal Medicine Jikei University School Of Medicine

• Miyamae Kouichi

  Department Of Urology Graduate School Of Medical Sciences Kumamoto University

• Masunaga Koichi

  Department Of Urology Tokyo Metropolitan Geriatric Hospital

• Nagata Takashi

  Department Of Urology Toshiba Hospital

• Yono Makoto

  Department Of Urology Graduate School Of Medical Sciences Kumamoto University

• Homma Yukio

  Department of Urology, Graduate School of Medicine, The University of Tokyo, Japan

• Nagata Takashi

  Department of Urology, Toshiba Hospital, Japan

関連論文

• Antiferromagnetic Ordering in the Spin Ladder Compound; Sr_Ca_xCu_O_
• Antiferromagnetic Ordering in the Spin Singlet State of the Ladder/Chain Material:Sr_Ca_Cu_O_
• Radical prostatectomy and adjuvant endocrine therapy for prostate cancer with or without preoperative androgen deprivation : Five-year results
• Endocrine therapy with or without radical prostatectomy for T1b-T3N0M0 prostate cancer
• Early results of radical prostatectomy and adjuvant endocrine therapy for prostate cancer with or without preoperative androgen deprivation
• Preoperative Endocrine Therapy for Clinical Stage A_2, B, and C Prostate Cancer: An Interim Report on Short-Term Effects
• Estimate Criteria for Efficacy of Treatment in Benign Prostatic Hyperplasia
• Estimate Criteria for Diagonsis and Severity in Benign Prostatic Hyperplasia
• Estrogen receptor-binding fragment-associated gene 9 expression and its clinical significance in human testicular cancer
• The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction: Pathophysiology and Pharmacotherapy of Overactive Bladder
• Near Infrared Spectroscopy study of the central nervous activity during artificial changes in bladder sensation in men
• Cancer-related pain and quality of life in prostate cancer patients : Assessment using the Functional Assessment of Prostate Cancer Therapy
• Long-term outcome of endoscopic biopsy and subsequent nephroureterectomy for upper urinary tract tumor
• Injection of Glutaraldehyde Cross-Linked Collagen for Urinary Incontinence: Two-Year Efficacy by Self-Assessment
• Measurement of Free and Bound Alcohol Metabolites and Methanol in Human Biological Samples : free and bound alcohol metabolites and methanol in acute alcohol administration
• Psychometric validation of the Japanese version of the International Consultation on Incontinence Questionnaire-Short Form
• Preoperative Endocrine Therapy for Clinical Stage A_2, B, and C Prostate Cancer: An Interim Report on Short-Term Effects
• Eulicin Inhibits Human Immunodeficiency Virus Infection and Replication
• Basic and Clinical Aspects of Non-neuronal Acetylcholine : Expression of Non-neuronal Acetylcholine in Urothelium and Its Clinical Significance
• Epidemiologic Survey of Lower Urinary Tract Symptoms in Asia and Australia Using the International Prostate Symptom Score
• TREATMENT OF BENIGN PROSTATIC HYPERPLASIA WITH HIGH INTENSITY FOCUSED ULTRASOUND: AN INITIAL CLINICAL TRIAL IN JAPAN WITH MAGNETIC RESONANCE IMAGING OF THE TREATED AREA
• Chemohormonal therapy as primary treatment for metastatic prostate cancer : A randomized study of estramustine phosphate plus luteinizing hormone-releasing hormone agonist versus flutamide plus luteinizing hormone-releasing hormone agonist
• High-Pressure Transport Properties of the Superconducting Spin-Ladder System Sr_Ca_xCu_O_
• Superconductivity in the Ladder Material Sr_Ca_Cu_O_
• Spatially Modulated Antiferromagnetism in Sr_Ca_Cu_O_ Probed by Muon Spin Relaxation : Condensed Matter: Electronic Properties, etc.
• Polymorphism of cytochrome P450 2B6 and prostate cancer risk : A significant association in a Japanese population
• Clinical guidelines for interstitial cystitis and hypersensitive bladder syndrome
• Japanese guideline for diagnosis and treatment of interstitial cystitis
• Carcinosarcoma in the Region of the Female Urethra
• A randomized, double-blind, placebo- and propiverine-controlled trial of the novel antimuscarinic agent imidafenacin in Japanese patients with overactive bladder
• Differential expression of estrogen-related receptors β and γ (ERRβ and ERRγ) and their clinical significance in human prostate cancer
• GT-Guided Acetic Acid Injection Therapy for Aldosterone-Producing Adrenocortical Adenoma : A Preliminary Report of Three Cases
• Transurethral Ultrasound-Guided Laser Induced Prostatectomy
• INCREASED INCIDENTAL DETECTION AND REDUCED MORTALITY IN RENAL CANCER - RECENT RETROSPECTIVE ANALYSIS AT EIGHT INSTITUTIONS
• Transurethral Ultrasound-guided Laser-induced Prostatectomy (TULIP) for Benign Prostatic Hyperplasia : A One-Year Follow-up Study
• A randomized, double-blind, placebo-controlled phase II dose-finding study of the novel anti-muscarinic agent imidafenacin in Japanese patients with overactive bladder
• Optimal Conditions to Induce Rat Adrenal Medullary Changes, Such as Pheochromocytoma, by Nicotine
• Predictability of Conventional Tests for the Assessment of Bladder Outlet Obstruction in Benign Prostatic Hyperplasia
• MAXIMUM FLOW RATE - THE SINGLE UROFLOWMETRIC PARAMETER IN CLINICAL TRIALS FOR BENIGN PROSTATIC HYPERPLASIA?
• THE THREE-CIRCLE SINGLE J CATHETER: A MORE STABLE URETHRAL CATHETER FOR PRESSURE FLOW STUDIES
• RESPONSE CRITERIA FOR THE THERAPEUTIC EFFICACY OF TREATMENT FOR BENIGN PROSTATIC HYPERPLASIA
• Clinical guideline for male lower urinary tract symptoms
• Clinical guidelines for overactive bladder
• Long-term safety, tolerability, and efficacy of the novel anti-muscarinic agent imidafenacin in Japanese patients with overactive bladder
• Immunohistochemical detection of advanced glycation end products in human bladder with specific monoclonal antibody
• Expression of two isozymes of acyl-coenzyme A : Cholesterol acyltransferase-1 and -2 in clear cell type renal cell carcinoma
• Glycolaldehyde-Modified Low Density Lipoprotein Leads Macrophages to Foam Cells via the Macrophage Scavenger Receptor^1
• Flux Line Lattice Structure in YNi_2B_2C(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
• Lower urinary tract symptomatology : Its definition and confusion
• Urologic Morbidity and Its Influence on Global Satisfaction with Treatment Outcome after Radical Prostatectomy for Prostate Cancer
• Future research needs for the definition/diagnosis of interstitial cystitis
• Magnetism and Superconductivity in Er_Tb_xNi_2B_2C (x=0.2 and 0.3)(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
• Hormonal therapy for prostate cancer : Current topics and future perspectives
• How frequent are invasive therapies required in patients receiving tamsulosin for benign prostatic hyperplasia? A retrospective long-term study
• Hyperthermic Treatment of Benign Prostatic Hyperplasia by a Prostathermer
• Long-term safety, tolerability and efficacy of extended-release tolterodine in the treatment of overactive bladder in Japanese patients
• Subcapsular Hematoma and Hypertension Following Percutaneous Needle Biopsy of a Transplanted Kidney
• Transient anuria requiring nephrostomy after intravesical bacillus Calmette-Guerin instillations for superficial bladder cancer
• Clinical guidelines for nocturia
• Oncolytic virus therapy for prostate cancer
• Electroporation-mediated muscarinic M_3 receptor gene transfer into rat urinary bladder
• Bilateral Tonic Pupils Associated with Neurosyphilis
• Efficacy of low dose tamsulosin in medical expulsive therapy for ureteral stones in Japanese male patients : A randomized controlled study
• Editorial Comment to Intravesical prostatic protrusion predicts clinical progression of benign prostatic enlargement in patients receiving medical treatment
• CS1-3 Pharmacological Treatment(Comprehensive Study 1「Treatment Strategy for Obstinate Urinary Incontinence」)
• Pharmacologic Actions of Temiverine (p-INN) and its Active Metabolite, RCC-36, on Isolated Human Urinary Bladder Muscle
• Pharmacological effects of propiverine and its active metabolite, M-1, on isolated human urinary bladder smooth muscle, and on bladder contraction in rats
• Prostaglandin E_2 release from isolated bladder strips in rats with spinal cord injury
• Effect of Cyclosporin A on Isolated Rabbit Bladder and Urethral Smooth Muscle
• The primitive rhodophyte Cyanidioschyzon merolae contains a semiamylopectin-type, but not an amylose-type, α-glucan
• IDENTIFICATION AND CHARACTERIZATION OF VISUAL PIGMENTS OF THE JUMPING SPIDER(Physiology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
• Interleukin-1 deficiency in combination with macrophage depletion increases susceptibility to Pseudomonas aeruginosa bacteremia
• Comparison of the distribution patterns of BK polyomavirus lineages among China, Korea and Japan : Implications for human migrations in northeast Asia
• WS1-4-4 Anticholinergic Drugs can Suppress Non-neuronal ATP Release from Human Bladder Urothelium(Urodynamic, Prostate and Urethra)
• Immunohistochemical localization of lysosomal cysteine protease cathepsins B and L in monkey hippocampal neurons after transient ischemia
• Electrocatalytic O_2 Evolution from Water at an ITO Electrode Modified with [Ru(terpy){4,4'-(CH_2PO_3H_2)_2-2,2'-bpy}(OH_2)]^ : Evidence for a Unimolecular Pathway
• Oxygen Evolution from Water Catalyzed by Mononuclear Ruthenium Complexes with a Triazamacrocyclic Ligand in a Facial Fashion
• A Maritime Lifesaving Solar Distiller
• Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10
• Kinetically Controlled Separation of Cadmium (II) from Zinc (II) with Dithizone in the Presence of Nitrilotriacetic Acid
• Tentorial Schwannoma Mimicking Meningioma : Case Report
• The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction : Pathophysiology and Pharmacotherapy of Overactive Bladder
• Idiopathic retroperitoneal fibrosis, inflammatory aortic aneurysm, and inflammatory pericarditis-Retrospective analysis of 11 case histories
• Botulinum toxin A submucosal injection for refractory non-neurogenic overactive bladder : Early outcomes
• Management trends, angioembolization performance and multiorgan injury indicators of renal trauma from Japanese administrative claims database
• Surgical procedures for benign prostatic hyperplasia : A nationwide survey in Japan
• Renoprotective effect of erythropoietin in ischemia/reperfusion injury : Possible roles of the Akt/endothelial nitric oxide synthase-dependent pathway
• Higher transfusion rate in bipolar transurethral resection of the prostate : Is it real?
• A case of calculus in the true ureteral diverticulum
• New clinical evidence of silodosin, an α_ selective adrenoceptor antagonist, in the treatment for lower urinary tract symptoms
• Bladder endometriosis developed after long-term estrogen therapy for prostate cancer
• Contracted bladder developing after prostate brachytherapy
• Dopamine-secreting corticomedullary mixed tumor of the adrenal gland
• Core lower urinary tract symptom score (CLSS) for the assessment of female lower urinary tract symptoms : A comparative study
• Comparisons of perioperative outcomes and costs between open and laparoscopic radical prostatectomy : A propensity-score matching analysis based on the Japanese Diagnosis Procedure Combination database
• Naftopidil vs silodosin in medical expulsive therapy for ureteral stones : A randomized controlled study in Japanese male patients
• Admissions related to interstitial cystitis in Japan : An estimation based on the Japanese Diagnosis Procedure Combination database
• Outline of JUA clinical guidelines for benign prostatic hyperplasia
• Assessment of Cervical Spondylotic Myelopathy Using Diffusion Tensor Magnetic Resonance Imaging Parameter at 3.0 Tesla
• Reassessment of the UICC revision of T3 renal cell carcinomas in a Japanese institute

もっと見る 閉じる

スポンサーリンク