Assessment of Mechanisms Involved in Antinociception Caused by Myrsinoic Acid B

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概要

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• Myrsinoic acid B (AMB) is a prenylated-benzoic acid derivative isolated from the Rapanea genus. Recent studies suggest that AMB has antihyperalgesic and antinociceptive properties in different animal models. The present study was designed to investigate the mechanisms involved in antinociception elicited by AMB (60 mg/kg) when administered by intraperitonial route (i.p.) in mice. The antinociceptive response of the compound was characterized by a reduction in contractions of the abdominal muscle, together with stretching of the hind limbs in response to i.p. injection of acetic acid (0.6%, 0.45 ml/mouse). The antinociception caused by AMB in the acetic acid test was significantly attenuated by i.p. treatment of mice with nitric oxide precursor, (L-arginine, 600 mg/kg), α2 and α1-adrenoceptor antagonists (yohimbine, 0.2 mg/kg/prazosin, 0.2 mg/kg), p-chlorophenylalanine (PCPA) an inhibitor of serotonin synthesis (100 mg/kg), 1-(2-methoxyphenyl)-4-(4-phthalimidobutyl)piperazine (NAN 190), a 5-HT1A selective receptor antagonist (0.5 mg/kg) and a non-selective cholinergic antagonist (atropine, 10 mg/kg). Its action was also modulated by the adrenal-gland hormones. In contrast, antinociception was not affected by naloxone (non-selective opioid receptor antagonist, 1.0 mg/kg), phaclofen (2.0 mg/kg) and bicuculline (1.0 mg/kg) GABAB and GABAA receptor antagonists, respectively, ondansetron (0.3 mg/kg) and ketaserin (1.0 mg/kg), (5-HT3 and 5-HT2 receptors, respectively) and haloperidol (0.2 mg/kg), a non-selective dopaminergic receptor. The antinociceptive effects are not related to muscle-relaxant or sedative action. These results indicate that AMB produces antinociception through mechanisms that involve interaction with L-arginine–nitric oxide, the serotonergic and cholinergic systems, as well as interaction with the α-adrenoceptors.

著者

• Hess Sarai

  Centro de Ciências da Saúde/Programa de Mestrado em Ciências Farmacêuticas, Universidade do Vale do

• Padoani Cristina

  Nucleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí

• Scorteganha Laiana

  Nucleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí

• Holzmann Iandra

  Nucleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí

• Malheiros Angela

  Centro de Ciências da Saúde/Programa de Mestrado em Ciências Farmacêuticas, Universidade do Vale do

• Yunes Rosendo

  Departamento de Química, Universidade Federal de Santa Catarina, Campus Universitário Trindade

• Delle Monache

  Istituto di Chimica, Università Cattolica

• de Souza

  Centro de Ciências da Saúde/Programa de Mestrado em Ciências Farmacêuticas, Universidade do Vale do

• Delle Monache

  Istituto Chimica Riconoscimento Molecolare Universita Cattolica S. Cuore

• Yunes Rosendo

  Departamento De Quimica Universidade Federal De Santa Catarina (ufsc)

• De Souza

  Centro Apt Citros Sylvio Moreira Instituto Agronomico

• Malheiros Angela

  Centro De Ciencias Da Saude/programa De Mestrado Em Ciencias Farmaceuticas Universidade Do Vale Do I

• Delle Monache

  Istituto di Chimica, Università Cattolica

• Malheiros Angela

  Centro de Ciências da Saúde/Programa de Mestrado em Ciências Farmacêuticas, Universidade do Vale do Itajaí

• Holzmann Iandra

  Nucleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí

• Hess Sarai

  Centro de Ciências da Saúde/Programa de Mestrado em Ciências Farmacêuticas, Universidade do Vale do Itajaí

• Scorteganha Laiana

  Nucleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí

• de Souza

  Centro de Ciências da Saúde/Programa de Mestrado em Ciências Farmacêuticas, Universidade do Vale do Itajaí

• Yunes Rosendo

  Departamento de Química, Universidade Federal de Santa Catarina, Campus Universitário Trindade

• Padoani Cristina

  Nucleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí

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