Glucose Intolerance in Japanese Patients with Obstructive Sleep Apnea
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概要
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Objective Obstructive sleep apnea syndrome (OSAS) often accompanies obesity and diabetes mellitus. This study was performed to investigate the prevalence of glucose intolerance and to determine independent predictors for insulin resistance in patients with OSAS. Methods A cross-sectional study of 679 OSAS patients with an apnea-hypopnea index (AHI)≥5/h and 73 controls subjects (AHI<5/h) was done in a tertiary university-based medical center. They were assessed by nocturnal polysomnography and underwent an oral glucose tolerance test. Results The prevalence of diabetes mellitus in OSAS patients was higher than that of the control group (25.9% vs. 8.2%, p<0.001) and 424 patients (62.4%) received a new diagnosis of impaired glucose tolerance or diabetes mellitus. The very severe OSAS group (AHI ≥45/h) had significantly higher homeostasis model assessment of insulin resistance (HOMA-IR) and HOMA beta-cell function than the other OSAS groups (AHI<45/h) and the control group. In a logistic regression model adjusting for potential confounders: age, AHI, minimum SpO2 and body mass index (BMI), only BMI was associated with insulin resistance (HOMA-IR>3) (odds ratio: 1.272, 95% confidence interval 1.206-1.343, p<0.0001). Conclusion Glucose intolerance was more common in patients with OSAS. Insulin resistance was associated not with AHI but rather with BMI.
- 社団法人 日本内科学会の論文
著者
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Shiomi Toshiaki
Sleep Disorders Center Aichi Medical University
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Hasegawa Rika
Sleep Disorders Center and Department of Cardiology, Aichi Medical University School of Medicine
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Otake Kazuo
Sleep Disorders Center Aichi Medical University Hospital
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Banno Katsuhisa
Sleep Disorders Center Aichi Medical University Hospital
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Sasanabe Ryujiro
Sleep Disorders Center Aichi Medical University Hospital
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Banno Katsuhisa
Sleep Disorders Center, Aichi Medical University Hospital
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Hori Reiko
Sleep Disorders Center, Aichi Medical University Hospital
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Okura Yoshihito
Sleep Disorders Center, Aichi Medical University Hospital
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Yamanouchi Kunio
Sleep Disorders Center, Aichi Medical University Hospital
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Hasegawa Rika
Sleep Disorders Center, Aichi Medical University Hospital
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