Diabetic Striatal Disease: Clinical Presentation, Neuroimaging, and Pathology
スポンサーリンク
概要
- 論文の詳細を見る
Background Unilateral movement disorders and contralateral neuroimaging abnormalities of the striatum have been sporadically reported as a rare syndrome associated with diabetes mellitus. Despite characteristic imaging findings and clinical manifestations, the mechanism underlying this syndrome is still unclear. Methods Six patients with this syndrome were studied clinically and subjected to MRI neuroimaging; one underwent biopsy of the striatum, and another underwent additional MR spectroscopy at 3.0T and FDG-PET. Results Neuroimaging findings were characterized by a T1-hyperintense unilateral lesion restricted to the striatum, contralateral to the symptomatic limbs. The biopsied striatum contained patchy necrotic tissue, severe thickening of all layers of arterioles, and marked narrowing of vessel lumens. Hyaline degeneration of the arteriolar walls, extravasation of erythrocytes, and prominent capillary proliferation were also notable, together with lymphocytic infiltration and macrophage invasion. In one patient, PET examination revealed decreased accumulation of FDG in the lesion. The MR spectrum for the diseased striatum revealed a decrease in the NAA/Cr ratio (1.35), normal Cho/Cr ratio (1.22), and a peak for myoinositol, while the spectrum on the contralateral site revealed a decrease in the NAA/Cr ratio (1.48), increase in Cho/Cr (1.32), but no peak for myoinositol. Conclusion The constellation of signs and symptoms and neuroimaging characteristics in previous reports and the six additional cases described here with neuropathological data and findings of MR spectroscopy appears unique enough to be termed "diabetic striatopathy." This syndrome appears in poorly controlled diabetics due to obliterative vasculopathy with prominent vascular proliferation, vulnerability to which is restricted to the striatum.
- 社団法人 日本内科学会の論文
著者
-
Kubo Jin
Department Of Neurology And First Department Of Internal Medicine Dokkyo University School Of Medici
-
Yamamoto Teiji
Department Of Electronics Faculty Of Technology Kanazawa University
-
Abe Yoshinori
Department Of Chemistry Graduate School Of Engineering Science Osaka University
-
Soeda Tomoko
Department Of Neurology Fukushima Medical University School Of Medicine
-
Ishihara Tetsuya
Department Of Neurology Dokkyo University School Of Medicine
-
Tanno Yoshihiro
Department Of Cell Science Institute Of Biomedical Sciences Fukushima Medical University School Of M
-
Katayama Soichi
Department Of Neurology And First Department Of Internal Medicine Dokkyo University School Of Medici
-
Kumagai Tomohiro
Department Of Neurology Fukushima Medical University School Of Medicine
-
Ishihara Tetsuya
Department of Neurology, Southern Tohoku Research Institute for Neuroscience
-
Katayama Soichi
Department of Neurology, Southern Tohoku Research Institute for Neuroscience
-
Kubo Jin
Department of Neurology, Southern Tohoku Research Institute for Neuroscience
関連論文
- Scattering Linear Polarizer Based on a Polymer Blend of Photo-cross-linkable Polymer Liquid Crystal and Photoinactive Polymer
- Thermally Stable Photoalignment Layer of a Novel Photo-Crosslinkable Polymethacrylate for Liquid Crystal Display : Structure and Mechanical and Thermal Properties of Condensed Matter
- Functionalized Mesogenic Composite for Photorefractive Applications
- Optical Anisotropy of Photo - Crosslinkable Polymer Film and Photoalignment Control of Nematic Liquid Crystals Using Nonpolarized Ultraviolet Irradiation
- Quantitative Evaluation of Motor Activity in Chronic Obstructive Pulmonary Disease Using Actigraph
- A Wavelength Tunable Q-Switched Erbium-Doped Fiber Laser with Fiber Bragg Grating Mirrors
- Brainstem function in rapid eye movement sleep behavior disorder : The evaluation of brainstem function by proton MR spectroscopy (^1H-MRS)
- Photocontrol of Thermlally Induced Reorientation of Amorphous Composite Film with Photo-Crosslinkable Polymer Liquid Crystal and Non-Liquid Crystalline Rodlike Monomer : Structure and Mechanical and Thermal Properties of Condensed Matter
- Data Processing for Obtaining Atomic Images from SrTiO_3 X-Ray Fluorescence Hologram
- Atomic-Resolution X-Ray Fluorescence Holography of Zn(0.02wt%)in a GaAs Wafer
- X-Ray Fluorescence Holography of SrTiO_3 Compared with X-Ray Photoelectron Holography
- 56. The Treatment of the Intracranial Aneurysm. Preliminary Report of Thrombosis Formation Utilizing Stereotactic Magnetically Cotrlled Iron Particles
- Expression of sonic hedgehog signal transducers, patched and smoothened, in human basal cell carcinonma
- P-18 Effect of shear stress on three-dimensional microvessel network formation of endothelial cells
- Hydride Vapor Phase Epitaxy of GaN on NdGaO_3 Substrate and Realization of Freestanding GaN Wafers with 2-inch Scale
- Hydride Vapor Phase Epitaxy of GaN on NdGaO_3 Substrate and Realization of Freestanding GaN Wafers with 2-inch Scale
- Electroluminescence of AlAs/GaAs Disordered Superlattices
- Photoluminescent Properties of AlAs/Al_xGa_As (x=0.5) Disordered Superlattices
- Absorption Spectra and Photoluminescent Processes of AlAs/GaAs Disordered Superlattices
- Proposal and Experimental Results of Disordered Crystalline Semiconductors
- Excimer-Type Electroluminescence and Carrier-Transporting Properties of Electron-Accepting π-Conjugated Polymers
- X-ray and thermal studies on the crystalline phases of normal alkanethiols n-CnH2n+1SH (n=18, 19, 22, 23, 24)
- A Novel Diffusion Resistant P-Base Region Implantation for Accumulation Mode 4H-SiC Epi-Channel Field Effect Transistor
- A Novel Diffusion Resistant P-Base Region Implantation for Accumulation-Mode 4H-SiC Epi-Channel Field Effect Transistor
- Comparison of Packing Modes of Poly (thiophene)s and Poly (thiazole)s
- Photoregulated Liquid Crystal Alignment on Photoreactive Side-Chain Liquid-Crystalline Polymer
- Scanning Capacitance Microscopy as a Characterization Tool for Semiconductor Devices
- Intermolecular π-π Interraction of Poly (4, 4'-dialkyl -2, 2'-bithiazole - 5, 5'-diyl) s and Photoluminescence of the Polymers
- Lifecorder : A New Device for the Long-term Monitoring of Motor Activities for Parkinson's Disease
- Scanning Capacitance Microscopy as a Characterization Tool for Semiconductor Devices
- Transport of 5-Fluorouracil and Its Derivatives through Human Erythrocyte Membrane
- Primary Sjogren's syndrome with myalgia mimicking dermatomyositis
- Electrical and Structural Properties of Amorphous In-Se Films Prepared by Flash Evaporation
- Characterization of Serum Anti-Phospholipid Antibodies in Patients with Multiple Sclerosis
- Uniform poly(methyl methacrylate) stereostars : synthesis, separation and stereocomplex formation
- Intracranial Invasive Aspergillosis Originating in the Sphenoid Sinus : A Successful Treatment with High-Dose Itraconazole in Three Cases
- A Benign Form of Isolated Angiitis of the Central Nervous System in Puerperium: An Identical Disorder to Postpartum Cerebral Angiopathy ?
- Incidence of Genetic Subgroups of Hereditary Spinocerebellar Ataxia in Fukushima Prefecture
- Early Diagnosis of Vertebral Dissecting Aneurysm : A Magnetic Resonance Angiography Study
- Secretion of Human Atrial Natriuretic Peptide in Response to Atrial Pacing and Its Function in Patients with Ventricular Septal Defect
- Ulcerative Colitis Associated with Takayasu's Disease.
- Diabetic Striatal Disease: Clinical Presentation, Neuroimaging, and Pathology
- CORRELATIONS AMONG HEAVY METALS IN BLOOD AND URINE AND THEIR RELATIONS TO DEPRESSIVE SYMPTOMS IN PARKINSON'S DISEASE PATIENTS