Late Reperfusion of A Totally Occluded Infarct-Related Artery Increases Granulocyte-Colony Stimulation Factor and Reduces Stroma-Derived Factor-1.ALPHA. Blood Levels in Patients With Ongoing Ischemia After Acute Myocardial Infarction

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概要

• 論文の詳細を見る

• After acute myocardial infarction (AMI), reopening of a totally occluded infarct-related artery (IRA) at a subacute stage is still controversial in symptom-free patients. However, in patients with persistent ischemic symptoms and inadequate collaterals to the in-farct area, recanalization is thought to provide beneficial effects. In addition to augmenting myocardial perfusion, we hypothesized that the benefit of recanalization involves the manipulation of circulating stem cell-mobilizing cytokines. This study included 30 patients with a totally occluded IRA and ongoing ischemic symptoms (the study group) and 30 patients with a partially occluded IRA (the control group). All patients underwent successful angioplasty and/or stenting. Before and immediately after the coronary intervention, blood granulocyte-colony-stimulating factor (G-CSF), stem-cell factor (SCF), vascular endothelial growth factor (VEGF), and stroma-derived factor-1 (SDF-1α) were measured. After recanalization, G-CSF levels significantly increased in the study group compared to the control group (P = 0.03). SDF-1α levels in the study group decreased relative to the controls (P = 0.02). However, no significant changes in VEGF or SCF levels between the two groups were found. In the multivariate analysis, reopening of a totally occluded IRA was independently and significantly associated with changes in G-CSF and SDF-1α levels after recanalization. In conclusion, our data suggest that the benefits of late reperfusion of a totally occluded IRA in patients with ongoing myocardial ischemia may involve mechanisms associated with stem cell-mobilizing and plaque-stabilizing cytokines. This study provides the rationale to investigate serial changes in cytokines and the numbers of circulating progenitors after reperfusion in the future.

• International Heart Journal刊行会の論文

著者

• Wang Chao-hung

  Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital

• Cherng Wen-jin

  Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital

• Chen Shih-jen

  Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital

• Kuo Li-Tang

  Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine

• Wang Chao-Hung

  Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine

• Yang Ning-I

  Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine

• Lee Chen-Chin

  Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine

• Cheng Chi-Wen

  Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine

• Verma Subodh

  Division of Cardiac Surgery, Toronto General Hospital, and Division of Cardiac Surgery, St. Michael's Hospital

• Verma Subodh

  Division of Cardiac Surgery, Toronto General Hospital, and Division of Cardiac Surgery, St. Michael's Hospital

• Verma Subodh

  Division of Cardiac Surgery, St. Michael's Hospital

• Cheng Chi-Wen

  Division of Cardiology, Chang Gung Memorial Hospital

• Chen Shih-Jen

  Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine

関連論文

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• VE-Cadherin^ α-Smooth Muscle Actin^+ Component of Vascular Progenitor Cells Correlates With the Coronary Artery Gensini Score
• Late Reperfusion of A Totally Occluded Infarct-Related Artery Increases Granulocyte-Colony Stimulation Factor and Reduces Stroma-Derived Factor-1.ALPHA. Blood Levels in Patients With Ongoing Ischemia After Acute Myocardial Infarction
• Total Detachment of Cardiac Myxoma Causing Saddle Embolization and Mimicking Aortic Dissection

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