Liquid-Phase Detection of Biological Targets with Magnetic Marker and Superconducting Quantum Interference Device
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概要
- 論文の詳細を見る
Liquid-phase detection of biological targets utilizing magnetic marker and superconducting quantum interference device (SQUID) magnetometer is shown. In this method, magnetic markers are coupled to the biological targets, and the binding reaction between them is detected by measuring the magnetic signal from the bound markers. Detection can be done in the liquid phase, i.e., we can detect only the bound markers even in the presence of unbound (free) markers. Since the detection principle is based on the different magnetic properties between the free and bound markers, we clarified the Brownian relaxation of the free markers and the Neel relaxation of the bound markers. Usefulness of the present method is demonstrated from the detection of the biological targets, such as biotin-coated polymer beads, IgE and Candida albicans.
著者
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TSUKAMOTO Akira
Advanced Research Laboratory, Hitachi, Ltd.
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YOSHINAGA Kohji
Department of Applied Chemistry, Kyushu Institute of Technology
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Kandori Akihiko
Advanced Research Laboratory Hitachi Ltd.
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ENPUKU Keiji
Research Institute of Superconductor Science and Systems, Kyushu University
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SUGIMOTO Yuki
Research Institute of Superconductor Science and Systems, Kyushu University
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TAMAI Yuya
Research Institute of Superconductor Science and Systems, Kyushu University
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MIZOGUCHI Takako
Advanced Research Laboratory, Hitachi Ltd.
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USUKI Naoki
R and D Division, Hitachi Maxell Ltd.
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KANZAKI Hisao
R and D Division, Hitachi Maxell Ltd.
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SUGIURA Yoshinori
Plastic Products Division, INOAC Corporation
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KUMA Hiroyuki
Faculty of Pharmaceutical Sciences, Nagasaki International University
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HAMASAKI Naotaka
Faculty of Pharmaceutical Sciences, Nagasaki International University
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