Confirmation of sable QTL that modifies the effects of the Ay allele on yellow coat color on mouse chromosome 1

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概要

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• F1-Ay mice between RR (aabbCC) and C57BL/6J-Ay (AyaBBCC) have a much darker yellow coat color than do C57BL/6J-Ay. Quantitative trait locus (QTL) analysis was carried out to identify genes responsible for the darker modification of the yellow coat color (this has been traditionally termed "sable"). A significant sable QTL was identified on chromosome 1 (Dmyaq4, LOD score 15.5 for lightness, and 13.4 for color difference), in a chromosomal position similar to that of Dmyaq2, a sable QTL previously identified in C3H/HeJ. Another significant sable QTL was identified on chromosome 4 (Dmyaq5, LOD score 5.6 for lightness, and 4.3 for color difference) near the tyrosinase-related protein 1 (Tyrp1) locus. The effect of Dmyaq5 was significant only in the presence of the RR allele at Dmyaq4, suggesting that the Dmyaq4 (as well as Dmyaq2) is a novel coat color gene that may act up-stream of Tyrp1 signaling to increase eumelanin production. (Edited by Masanori OTSUKA, M.J.A.)

• 日本学士院の論文

著者

• Suto Jun-ichi

  Div. Of Animal Sciences National Inst. Of Agrobiological Sciences

• SUTO Jun-ichi

  Department of Molecular Biology and Immunology, National Institute of Agrobiological Sciences

• Suto Jun-ichi

  Agrogenomics Res. Center National Inst. Of Agrobiological Sciences

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