Mechanisms of a tumor marker, glutathione transferase P, expression during hepatocarcinogenesis of the rat

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概要

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• The molecular mechanism of any tumor marker expression may shed a light on the mechanism of the particular tumorigenesis. This idea in mind, we have been pursuing the mechanism of specific induction of the placental type glutathione transferase (GST-P) gene during hepatocarcinogenesis of the rat. Making use of advanced technologies of molecular biology including proteomic analysis, gene cloning and production of specific transgenic rats etc., we were able to identify the enhancer and the activator proteins responsible for this tumor marker expression. Negative regulatory regions and modulatory proteins were also found. The overview of this long range study and the future outlook of the problem will be discussed. (Communicated by Kumao TOYOSHIMA, M.J.A.)

• 日本学士院の論文

著者

• MURAMATSU Masami

  Director, Research Center for Genomic Medicine, Saitama Medical University

• SAKAI Masaharu

  Professor, Dept. Health Sciences, Hokkaido University School of Medicine

関連論文

• Mechanisms of a tumor marker, glutathione transferase P, expression during hepatocarcinogenesis of the rat

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