Looking for cell-cell adhesion molecules: a cadherin story

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概要

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• Animal cells have the intrinsic ability to adhere to each other and to form multicellular structures. Classic studies suggested that cells have divalent cation-dependent mechanisms for holding themselves together. Cadherins were identified as Ca2+-sensitive cell surface molecules; and extensive studies revealed that this family of molecules plays critical roles in cell-to-cell adhesion and tissue organization, and even in synapse formation. Further studies showed that molecules belonging to the cadherin superfamily have more diverse functions, such as those to regulate planar cell polarity. Thus, we have been able to disclose parts of the molecular mechanisms of how animal cells can assemble and organize themselves into complex multicellular structures. (Contributed by Masatoshi TAKEICHI, M.J.A.)

• 日本学士院の論文

著者

• TAKEICHI Masatoshi

  RIKEN Center for Developmental Biology

関連論文

• Cadherins in neuronal morphogenesis and function
• Looking for cell-cell adhesion molecules: a cadherin story

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