Model describing the biased Brownian movement of myosin.

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概要

• 論文の詳細を見る

• A recent study with single molecule measurements has reported that myosin II, a molecular motor, generates stochastic and multiple steps during the hydrolysis of a single ATP molecule. In order to elucidate the mechanism for the motion of myosin, we traced the movements of individual molecules by simulating the Brownian movements along the potentials created by the interaction between a myosin molecule and an actin filament. We demonstrated that Brownian movement was biased to one direction as observed for myosins by either spatially tilting or temporally fluctuating the height of the potential. We incorporated the biased Brownian movement into an ATP hydrolysis reaction scheme and studied the effects of the load on the movement. The results could successfully explain the movements and mechanical properties of myosin. Thus, it was demonstrated that the movement of myosin is thermally driven and the random motion is biased by the energy released from the ATP hydrolysis.<BR><BR>(Communicated by Fumio OOSAWA, M. J. A., Jan. 14, 2003)

• 日本学士院の論文

著者

• Yanagida Toshio

  Graduate School Of Frontier Biosciences Osaka University:formation Of Soft Nano-machines Crest

• Yanagida Toshio

  Department Of Physiology And Biosignaling Osaka University Graduate School Of Medicine

• ESAKI Seiji

  Department of Physiology and Biosignaling, Graduate School of Medicine, Osaka University

• ISHII Yoshiharu

  Single Molecule Processes Project, ICORP, JST

関連論文

• OPTICAL COHERENCE TOMOGRAPHY SYSTEM DEVELOPED FOR THE STUDY OF MICROCIRCULATION
• Simultaneous Measurement of Individual ATPase and Mechanical Reactions by a Single Myosin Molecule at Work
• 1P273 Cooperativity causes plasticity in molecular motors(9. Molecular motor (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
• Model describing the biased Brownian movement of myosin.

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