Association of Serum Adiponectin Levels with All-Cause Mortality in Hemodialysis Patients
スポンサーリンク
概要
- 論文の詳細を見る
Objective Adiponectin (ADPN) has been shown to protect against cardiovascular disease for the general population with problematic metabolic syndrome. However, it remains unclear whether ADPN is associated with mortality in patients on maintenance hemodialysis (HD). Methods, Patients or Materials We selected 85 HD patients [51 men/34 women; mean age, 64±2 years; underlying kidney diseases, diabetic nephropathy in 36 patients (42.3%), chronic glomerulonephritis in 29 (34.1%), hypertensive nephrosclerosis in 10 (11.8%), and others in 10 (11.8%)] who survived for more than 3 months after the start of HD. We first measured serum ADPN levels and prospectively followed patients for the next 3 years. Results We were able to follow 74 of 85 patients; 59 survived, and 15 died. Serum log-transformed ADPN levels were negatively correlated with BMI (r=-0.43, p<0.01). Despite a similar BMI (20.7±0.8 vs. 20.3±0.4 kg/m2), the expired patients had significantly higher ADPN compared with the surviving patients (20.5 μg/ml [14.0-23.5] vs. 14.2 μg/ml [9.7-21.3], p<0.05). Cox-hazards multivariate regression analysis adjusted for conventional case-mix features (age, sex, and underlying kidney disease) revealed that serum ADPN became a significant determinant of all-cause mortality. There was a 10.3% risk increment for each 1-μg/ml increase in ADPN during the follow-up. Kaplan-Meier analysis revealed that patients with higher ADPN levels (≥15 μg/ml) had a significantly lower survival rate compared with those with lower ADPN levels (<15 μg/ml) (76 vs. 92%, p<0.05). Conclusion These results indicated that high rather than low ADPN independently predict total mortality in HD patients.
著者
-
SAKAKIMA Masanori
The First Department of Medicine, Hamamatsu University School of Medicine
-
Kato Akihiko
Division Of Blood Purification Hamamatsu University School Of Medicine
-
Fujigaki Yoshihide
The First Department Of Medicine Hamamatsu University School Of Medicine
-
Yamamoto Tatsuo
The First Department Of Medicine Hamamatsu University School Of Medicine
-
OHASHI Naro
The First Department of Medicine, Hamamatsu University School of Medicine
-
FUJIGAKI Yoshihide
The First Department of Medicine, Hamamatsu University School of Medicine
-
HISHIDA Akira
the First Department of Internal Medicine, Hamamatsu University School of Medicine
-
Misaki Taro
The First Department of Medicine, Hamamatsu University School of Medicine
関連論文
- Atypical Fabry's Disease Presenting with Cholesterol Crystal Embolization
- Glycine attenuates apoptotic cell death in uranyl acetate-induced acute renal failure in rats
- Stiff-person Syndrome Associated with Cerebellar Ataxia and High Glutamic Acid Decarboxylase Antibody Titer
- Clinicopathologic findings relevant to disappearance or relapse of proteinuria following corticosteroid treatment in IgA nephropathy patients with proteinuria of 0.5 to 2.0g/day
- evidence-based practice guideline for the treatment of chronic kidney disease
- Insulin-like growth factor-I increases p21 expression and attenuates cisplatin-induced acute renal injury in rats
- Longterm complete remission of AL-amyloid-related nephrotic syndrome
- Cytomegalovirus Colitis Following Immunosuppressive Therapy for Lupus Peritonitis and Lupus Nephritis
- Progressive Renal Failure and Blindness Due to Retinal Hemorrhage after Interferon Therapy for Hepatitis C Virus-associated Membranoproliferative Glomerulonephritis
- Rapid deterioration of renal function in a patient with multiple myeloma associated with amyloid and light chain depositions
- Association of Serum Adiponectin Levels with All-Cause Mortality in Hemodialysis Patients
- Giant Coronary Aneurysm in a Patient with Systemic Lupus Erythematosus
- A Japanese Case of Familial Mediterranean Fever with Family History Demonstrating a Mutation in MEFV
- High dose Chemotherapy and Stem Cell Support in a Patient of Light- and Heavy-chain Deposition Disease with Abnormal Marrow Cell Surface Antigens and No Monoclonal protein
- Siblings with Alport's syndrome showing unique staining patterns for α5(IV) and α6(IV) chains of collagen type IV
- A Patient with Sarcoidosis Presenting with Acute Renal Failure : Implication for Granulomatous Interstitial Nephritis and Hypercalcemia
- Glucose and Oxygen Hypometabolism in Aceruloplasminemia Brains
- Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney
- Accumulation of lanthanum carbonate in the digestive tracts
- Acquired resistance to rechallenge injury in rats that recovered from mild renal damage induced by uranyl acetate : accelerated proliferation and hepatocyte growth factor/c-Met axis
- Spontaneous Rupture of the Urinary Bladder Presenting as Oliguric Acute Renal Failure
- Cytomegalovirus Colitis Following Immunosuppressive Therapy for Lupus Peritonitis and Lupus Nephritis
- Biloma during Steroid Therapy for Minimal Change Nephrotic Syndrome.
- Spontaneous Bacterial Peritonitis in an Adult Patient with Nephrotic Syndrome.
- Reversible Acute Renal Failure in Idiopathic Nephrotic Syndrome.
- Progressive Renal Failure and Blindness Due to Retinal Hemorrhage after Interferon Therapy for Hepatitis C Virus-associated Membranoproliferative Glomerulonephritis.
- Nephrogenic Diabetes Insipidus Associated with Bilateral Ureteral Obstruction.
- Chronic Pyelonephritis Presenting as Multiple Tumor-Like Renal Lesions