Peak Expiratory Flow Variability Adjusted by Forced Expiratory Volume in One Second is a Good Index for Airway Responsiveness in Asthmatics
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概要
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Background The lowest peak expiratory flow (PEF) over a week, expressed as a percentage of the highest PEF (Min%Max PEF) has been reported to be the index that most closely correlates with airway hyperresponsiveness (AHR) in asthmatics. However, both fluctuation of the airway caliber and airflow limitation are regarded as physiological properties of asthma closely related to AHR. An accurate index that shows the degree of AHR may be obtained by combining the index of airway lability with the parameters that represent airway caliber. Methods Ninety-two steroid-naive and twenty-eight steroid-treated asthmatic patients were enrolled. Using the physiological parameters obtained from spirometry and PEF monitoring, we investigated the indices which correlate accurately with airway responsiveness measured by the inhalation challenge test. Results Although the methacholine threshold was related to all parameters that represent airway caliber and lability, Min%Max PEF had the strongest correlation with AHR. When Min%Max PEF was adjusted by the airway geometric factors, the normalization of Min%Max PEF with forced expiratory volume in one second as a percentage of the predicted value (%FEV1) improved the relationship between Min%Max PEF and AHR. Conclusions Min%Max PEF adjusted by %FEV1 showed a good correlation with airway responsiveness measured by the inhalation challenge test, and may be useful as a convenient alternative index of AHR in asthmatic patients
著者
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Ichinose Masakazu
The Third Department Of Internal Medicine Wakayama Medical University
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MINAKATA Yoshiaki
the Third Department of Internal Medicine, Wakayama Medical University, School of Medicine
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Ichikawa Tomohiro
The Third Department of Internal Medicine, Wakayama Medical University
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Ichikawa Tomohiro
The Third Department of Internal Medicine, Wakayama Medical University, School of Medicine
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Matsunaga Kazuto
The Third Department of Internal Medicine, Wakayama Medical University, School of Medicine
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Kanda Masae
The Third Department of Internal Medicine, Wakayama Medical University, School of Medicine
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Hayata Atsushi
The Third Department of Internal Medicine, Wakayama Medical University, School of Medicine
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Yanagisawa Satoru
The Third Department of Internal Medicine, Wakayama Medical University, School of Medicine
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Akamatsu Keiichiro
The Third Department of Internal Medicine, Wakayama Medical University, School of Medicine
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Koarai Akira
The Third Department of Internal Medicine, Wakayama Medical University, School of Medicine
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Hirano Tsunahiko
The Third Department of Internal Medicine, Wakayama Medical University, School of Medicine
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Sugiura Hisatoshi
The Third Department of Internal Medicine, Wakayama Medical University, School of Medicine
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Kanda Masae
The Third Department of Internal Medicine, Wakayama Medical University
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Koarai Akira
The Third Department of Internal Medicine, Wakayama Medical University
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Hirano Tsunahiko
The Third Department of Internal Medicine, Wakayama Medical University
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Akamatsu Keiichiro
The Third Department of Internal Medicine, Wakayama Medical University
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Matsunaga Kazuto
The Third Department of Internal Medicine, Wakayama Medical University
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Sugiura Hisatoshi
The Third Department of Internal Medicine, Wakayama Medical University
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Yanagisawa Satoru
The Third Department of Internal Medicine, Wakayama Medical University
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Minakata Yoshiaki
The Third Department of Internal Medicine, Wakayama Medical University
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Ichinose Masakazu
The Third Department of Internal Medicine, Wakayama Medical University, School of Medicine
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