The Effect of Senescence of Endothelial Progenitor Cells on In-stent Restenosis in Patients Undergoing Coronary Stenting
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概要
- 論文の詳細を見る
Objective: Restenosis after stent implantation is caused by endothelial cell damage and subsequent neointimal formation. The objective of this study is to elucidate the relevance of endothelial progenitor cells (EPCs) in the development of in-stent restenosis in patients undergoing stent implantation. Patients or Materials: The subjects were 46 patients who underwent coronary stenting. Blood samples were collected at the time of follow-up coronary angiography after coronary stenting. EPCs were isolated from blood samples and cultured. Their phenotypes were confirmed by uptake of acetylated low-density lipoprotein and binding of fluorescein isothiocyanate-labeled Ulex europaeus agglutinin 1 lectin. The number of colony-forming units (CFUs) and the senescent cells, determined by acidic β-galactosidase staining, was counted. Angiogenic growth factors secreted by EPCs, such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), hepatocyte growth factor (HGF), and macrophage chemoattractant protein (MCP-1) from the culture medium were also measured by enzyme-linked immunosorbent assay. Results: Patients with in-stent restenosis (defined as >40% stenosis, n=16) had a decreased number of CFUs (p<0.05), and increased senescent cells (p<0.05), compared to patients without restenosis (n=30). There was no significant difference of angiogenic growth factors (VEGF, HGF, b-FGF, and MCP-1) secreted by EPCs between the two groups. On multivariate analysis, an increased number of senescent EPCs was the indepen-dent factor associated with in-stent restenosis (OR 1.10, 95% CI 1.01 to 1.20). Conclusion: These data suggested that EPCs might be involved in the development of in-stent restenosis.
- 社団法人 日本内科学会の論文
著者
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Tomobuchi Yoshiaki
Department of Critical Care Medicine, Wakayama Medical University
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Kubo Takashi
Department of Cardiovascular Medicine, Wakayama Medical University
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Imanishi Toshio
Department Of Cardiovascular Medicine Wakayama Medical University
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Matsuo Yoshiki
Department Of Cardiovascular Medicine Wakayama Medical University
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Tomobuchi Yoshiaki
Department Of Cardiology Seiyu Memorial Hospital
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Kubo Takashi
Department Of Anesthesia Akane Foundation Tsuchiya General Hospital : Present Address: Department Of
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Akasaka Takashi
Department Of Cardiology Kawasaki Medical School
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Hano Takuzo
Department Of Cardiovascular Medcine Wakatama Medical University
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Hayashi Yasushi
Department Of Energy Sciences Tokyo Institute Of Technology
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