TrimethoprimSulfamethoxazoleInduced Hypersensitivity Syndrome Associated with Reactivation of Human Herpesvirus6

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概要

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• A 27yearold man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)sulfamethoxazole (SMX) treatment. After the withdrawal of TMPSMX and the administration of highdose steroid, these systemic symptoms gradually resolved. During the disease course, the patient showed a transient increase in antihuman herpesvirus (HHV)6 antibody titers and HHV6 DNA in the peripheral blood, indicating the reactivation of a latent HHV6 infection. This is the first case of TMPSMXinduced hypersensitivity syndrome associated with the reactivation of a latent viral infection.

著者

• Ohta Keisuke

  Department of Respiratory Medicine, Japanese Red Cross Medical Center

関連論文

• TrimethoprimSulfamethoxazoleInduced Hypersensitivity Syndrome Associated with Reactivation of Human Herpesvirus6

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