Switching from Premixed Human Insulin to Premixed Insulin Lispro: A Prospective Study Comparing the Effects on Glucose Control and Quality of Life
スポンサーリンク
概要
- 論文の詳細を見る
Aim To evaluate the clinical effects of switching from premixed human insulin to a premixed rapid-acting insulin analogue in type 2 diabetic patients. Research Design and Methods Thirty patients, who were treated with a twice-daily injection of premixed human insulin, were enrolled and randomized to (i) 50/50 premixed insulin lispro twice-daily at the same daily dose as premixed human insulin (analogue mix group), or (ii) continued premixed human insulin (control group). The doses of insulin were adjusted every month by registered diabetologists to achieve adequate blood glucose levels. At the beginning of the study, and again 4 months later, HbA1c and blood glucose levels were measured, and the amount of insulin required and BMI were recorded in both groups. Insulin therapy-related quality of life (ITR-QOL) and the diabetes treatment satisfaction questionnaire (DTSQ) were also assessed in the analogue mix group at the beginning of the study and again 4 months later. Results Although HbA1c levels did not change significantly over the duration of the study in the control group (7.33 ± 0.58 vs 7.29 ± 0.65%), HbA1c did improve significantly in the analogue mix group (7.59 ± 0.44 vs 7.24 ± 0.49%; p<0.05). The dose of insulin required in the analogue mix group did not change significantly (0.37 ± 0.11 vs 0.38 ± 0.14 U/kg/day), but increased in the control group from 0.34 ± 0.15 to 0.37 ± 0.16 U/kg/day (p<0.05). The switch to the premixed insulin analogue did not affect ITR-QOL and DTSQ scores. Conclusions This study showed that switching from premixed human insulin to 50/50 premixed insulin lispro improved blood glucose control without compromising QOL. This finding suggests that a premixed rapid-acting insulin analogue is more effective than human insulin for Japanese type 2 diabetic patients.
著者
-
Kawana Yukiko
Department Of Obstetrics And Gynecology University Of Tokyo
-
Yamada Satoru
Department Of Chemistry Graduate School Of Science Osaka University
-
Atsuda Koichiro
School Of Pharmaceutical Sciences Kitasato University
-
Shiono Kaoru
School Of Pharmaceutical Sciences Kitasato University
-
Kitaoka Akira
School Of Pharmaceutical Sciences Kitasato University
-
Irie Junichiro
Department Of Internal Medicine Kitasato Institute Hospital
-
Watanabe Mari
School of Pharmaceutical Sciences, Kitasato University
-
Tsukamoto Youko
Department of Nursing, Kitasato Institute Hospital
-
Kawana Yukiko
Department of Nursing, Kitasato Institute Hospital
関連論文
- Senior-Loken syndrome associated with mental retardation and microcephaly
- Ab Initio Size-Consistent Calculations of Effective Exchange Interactions in Mesoscopic Magnetic Clusters Composed of Triplet Methylenes and Quartet Nitrogen Atoms
- Theoretical and Experimental Studies of a Charge-Transfer Mechanism for Biomimetic Oxygenations of Phenol and Indol Derivatives
- Ab Initio Molecular Orbital Studies of Singlet Oxygen Reactions of Olefins, Enol Ethers, and Enamines
- PLAP-1 : A novel molecule regulating homeostasis of periodontal tissues
- Temperature Simulation of Cooling Process of Ge Droplets in Laser Droplet Epitaxy(Surfaces, Interfaces, and Films)
- Preparation of Twin- and Crack-Free LiNbO_3 Films by Pulsed Laser Ablation Using Nucleation Process at High Temperature : Surfaces, Interfaces, and Films
- Rotational Honeycomb Epitaxy of Ru Thin Films on Sapphire (0001) Substrate : Surfaces, Interfaces, and Films
- Enhanced Conversion Efficiencies of Cu_2ZnSnS_4-Based Thin Film Solar Cells by Using Preferential Etching Technique
- Effect of βtricalcium phosphate particle size on recombinant human platelet-derived growth factor-BB-induced regeneration of periodontal tissue in dog
- Application of 4-META/MMA-TBB resin for fixation of membrane to tooth in guided tissue regeneration in dog
- IS-3 Nasal Immunization of Mice with Peptide Having a Cross-neutralization Epitope on Minor Capsid Protein L2 of Human Papillomavirus(HPV)Type 16 Elicit Systemic and Mucosal Antibodies
- Preparation of Epitaxial Ge Film on Si by Pulsed Laser Ablation Using Molten Droplets
- Epitaxial Growth of Hexagonal CdS Films on Hydrogen-Terminated Si(111) Substrates
- Telmisartan but Not Candesartan Affects Adiponectin Expression In Vivo and In Vitro
- Dynamic Influence of the Two Membrane-Proximal Immunoglobulin-Like Domains upon the Peptide-Binding Platform Domain in Class I and Class II Major Histocompatibility Complexes: Normal Mode Analysis
- A Case of Uterine Choriocarcinoma with Spontaneous Rupture Twenty-Three Years following the Antecedent Pregnancy
- Effects of All-trans Retinoic Acid on Choriocarcinoma Cells in vitro
- β-tricalcium phosphate and basic fibroblast growth factor combination enhances periodontal regeneration in intrabony defects in dogs
- Correlation between Deposition of Immuno-Components and Infiltration Pattern of Polymorphonuclear Leukocytes in the Lesions of Chronic Urticaria
- Effect of Combination Therapy of a Rapid-Acting Insulin Secretagogue (Glinide) with Premixed Insulin in Type 2 Diabetes Mellitus
- Theoretical Study on the Second Hyperpolarizabilities for Small Radical Systems
- Theoretical Studies on the Second Hyperpolarizabilities of Trithiapentalene and Its Donor and Acceptor Disubstituted Species
- Negative Second Hyperpolarizability of the Nitronyl Nitroxide Radical
- Histopathological Study of the Characteristics of Bone Formation with Guided Bone Regeneration in Dogs-Localization of Alkaline Phosphatase Activity-
- Switching from Premixed Human Insulin to Premixed Insulin Lispro: A Prospective Study Comparing the Effects on Glucose Control and Quality of Life