The Influence of ATP Synthase 8, 6 Gene Polymorphisms on the Individual Difference of Endurance Capacity or its Trainability

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The purpose of the present study was to investigate the relationship between the polymorphisms of ATP synthase 8, 6 gene and the individual difference of the endurance capacity or its trainability. Sixty-nine sedentary adult males participated in an 8-week endurance training program and VO2max and ventilatory threshold (VT) was determined as the index of endurance capacity before and after training. The polymorphisms of ATP synthase 8, 6 genes were determined by direct sequence on total DNA that was extracted from venous blood. The VO2max increased from 41.7 to 47.8ml/min/kg (P<0.01), and VT increased from 26.9±5.6ml/min/kg to 31.9±6.8ml/min/kg (P<0.01). The polymorphism at 25 sites was detected in ATP 8, 6 gene. At mtDNA 8701, non-Cam group (n=50: VT/w=27.8±5.3ml/min/kg) had higher pre VT/wt than Cam group (n=19: VT/w=24.3±5.5ml/min/kg). The comparison of pre VT/LBM between Cam group and non-Cam group at mtDNA 8701 was also similar. We concluded that mtDNA ATP synthase 8, 6 gene might be associated with the individual difference in initial level of VT.