Lack of Association Between Perlecan Gene Intron 6 BamHI Polymorphism and Risk of Mitral Valve Prolapse in Taiwan Chinese
スポンサーリンク
概要
- 論文の詳細を見る
Abnormalities of proteoglycan, collagen, and elastic fibers were found in floppy mitral valves. Perlecan is one of the three major classes of heparan sulfate proteoglycans within the cardiovascular system. The role of perlecan genetic variant in mitral valve prolapse (MVP) has not been studied. We therefore performed a case-controlled study investigating the possible relation between the perlecan gene intron 6 BamHI polymorphism and MVP among the Chinese population in Taiwan. We studied 100 patients with MVP diagnosed by echocardiography and 100 age- and sex-matched normal control subjects. The perlecan gene intron 6 BamHI polymorphism was identified by polymerase chain reaction-based restriction analysis. There were no significant differences in either the genotype distribution or allelic frequencies between MVP cases and controls for perlecan gene intron 6 BamHI polymorphism (P = 0.20 and 0.76, respectively). Further categorization of the MVP patients into mild and severe subgroups also revealed no statistical difference from controls for perlecan gene intron 6 BamHI polymorphism. It is concluded that perlecan gene intron 6 BamHI polymorphism is not a suitable genetic marker of MVP in Taiwan Chinese
論文 | ランダム
- 「パチンコホールイノベーションフォーラム2010」開催
- 特論 ミトコンドリア由来代謝シグナルによるインスリン分泌制御研究の新展開 (新時代の糖尿病学(4)病因・診断・治療研究の進歩)
- 208.Otsuka Long-Evans Tokushima Fatty(OLETF)ラット骨格筋のピルビン酸脱水素酵素複合体(pyruvate dehydrogenase complex : PDC)活性がインスリン抵抗性に及ぼす影響(代謝)
- 炭水化物による遺伝子発現制御II. ピルビン酸キナーゼとインスリン遺伝子について
- 糖尿病ハタネズミとKKマウスにおける解糖系酵素活性と血漿インスリン値の変動