Early Development of 6-Sulfanilamidoindazole (6SAI)-Induced Histopathological Changes in Rats

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6-Sulfanilamidoindazole (6SAI)-induced arthritis is one of the models for testing anti-inflammatory agents. In this study, in order to clarify the early histopathological changes in this model, the detailed histopathological examination was carried out on various organs and tissues in rats orally administered with 6SAI daily dose: (500 mg/kg) for up to 7 days. There were no histopathological changes in the control animals throughout the experimental period. In the 6SAI-treated animals, focal monomuclear cell infiltration in the insertions of tendons and/or articular synovium was observed in the tarsal joints from 1 day after the first treatment (1D), and the change was followed by edematous inflammation in the synovium, peritenon, and periarticular connective tissues. In the liver, edema with mononuclear cell infiltration was observed in the portal regions from 1D, and hypertrophy and increase in number of sinusoidal cells were usually found at 7D. Inflammatory lesions were also sporadically seen in the serosal tissues of various organs at 5 and 7D. From 2D, almost all animals showed hypertrophy of thyroid gland epithelial cells. Pyknosis of thymic cortical lymphocytes and adrenal gland hypertrophy were also seen in some animals. The present study revealed the characteristics of the early systemic histopathological changes in the 6SAI-induced arthritis model, and suggested that there may be some relationships between the articular and hepatic changes.