Laxative Effect of Agarwood Leaves and Its Mechanism
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the laxative activity of an extract of agarwood leaves from Aquilaria sinensis. The laxative activity was measured in mice by counting the stool frequency and stool weight, and the drugs were orally administered. An acetone extract of agarwood leaves and senna (a representative laxative drug) both increased the stool frequency and weight, but a methanol extract did not. The laxative effect of the acetone extract was milder than that of the anthraquinoid laxative, senna, and the former did not induce diarrhea as a severe side effect. We identified the main constituent contributing to the laxative effect of the acetone extract as genkwanin 5-O-β-primeveroside (compound 4). Compound 4 strengthened the spontaneous motility and induced contraction in the ileum. This ileal contraction induced by compound 4 was inhibited by atropine, but not by azasetron, suggesting that the effect of compound 4 was mediated by acetylcholine receptors, and not by serotonin. The laxative mechanism for compound 4 may in part involve stimulation of intestinal motility via acetylcholine receptors.
論文 | ランダム
- オージェ電子スペクトロスコピーによるシリコン表面の不純物の分析(研究ノート)
- 超高真空技術(実験技術シリーズ"新しい実験法-9-")
- 「敬宇文稿」の年代推定について
- 基調講演 騒音政策と戦略的騒音調査の展開 (社団法人日本騒音制御工学会〔平成17年〕春季研究発表会講演論文集) -- (騒音政策の展開(1))
- Is cytogenetic diagnosis of 46,XX karyotype spontaneous abortion specimens erroneous? Fluorescence in situ hybridization as a confirmatory technique