Quantitative Structure-activity Relationships of Antifungal 1 -(3, 5-Dichlorophenyl)-2, 5-pyrrolidinediones and 3-(3, 5-Dichlorophenyl)-2, 4-oxazolidinediones

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The antifungal activity of 22 derivatives of 1-(3, 5-dichlorophenyl)-2, 5-pyrrolidinedione and 6 derivatives of 3-(3, 5-dichlorophenyl)-2, 4-oxazolidinedione, having various substituents on the imido rings, against Botrytis cinerea was determined by the agar medium dilution method. The structure-activity relationships were analyzed using the physicochemical parameters of the molecules: such as the hydrophobic log P, the electronic σ*, and the steric Esc values with the multiple regression technique. Only the hydrophobic effect is significant in determining the activity variations of both series of compounds. Furthermore, the structure-activity relationships of these two series of compounds are represented by an identical equation, having only the hydrophobic term as a variable.
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