Quantitative Analysis of Sandwiching Recycle Technique in Preparative Linear Chromatography

概要

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A new recycling technique named “Sandwiching recycle” is investigated, and its effectiveness in obtaining high recovery yields of the desired component from a multicomponent mixture by means of chromatographic separation is examined. This technique hinders the product from diffusion in such a way that the feed period is sandwiched in between the recycle periods. It is found that sandwiching recycle chromatography is highly effective to increase the yield of the component whose mean retention time is equivalent to its switching time, but that this recycling does not increase the yield of the impure component in the product. Because of the simpleness of its apparatus, this technique can be used for preparative scale separation of mixtures. Detailed features of the recycling method are examined by simulation to recognize what conditions should be taken into consideration to separate the target component from a mixture and to obtain high yield.