Coexpression of Ang1 and Tie2 in Odontoblasts of Mouse Developing and Mature Teeth—A New Insight into Dentinogenesis
スポンサーリンク
概要
- 論文の詳細を見る
Agiopoieten regulates vascular angiogenesis and stabilization, and is reported to promote bone formation by facilitating angiogenesis. To estimate the role of Ang1 in odontogenesis, we explored the distribution of Ang1 and the receptor, Tie2 in the mouse developing and mature first molar of the mandible. At embryonic day 18, when differentiation of odontoblasts begins, immunosignals for Ang1 were intensely detected in the basement membrane and the distal side, which faced the basement membrane of odontoblasts. In situ hybridization revealed that Ang1 was expressed in odontoblasts and ameloblasts facing the basement membrane. Tie2 was localized in the distal side of odontoblasts. After birth, Ang1 was detected in the predentin, whereas both Ang1 and Tie2 were colocalized in odontoblasts and odontoblast processes. These distributions were retained up to 8 weeks. In contrast to odontoblasts, ameloblasts, cementoblasts and osteoblasts expressed Ang1 but did not express Tie2. Colocalization of Ang1 and Tie2 in odontoblasts and selective expression of Tie2 in odontoblasts among cells responsible for calcified tissue formation suggested the involvement of autocrine signals of Ang1-Tie2 in dentinogenesis.
- 日本組織細胞化学会の論文
- 2014-02-27
日本組織細胞化学会 | 論文
- PII-27 中耳真珠腫に於ける5-FU軟膏局所投与の組織細胞化学的検討 : 角化細胞増殖因子(KGF)およびその受容体(KGFR)発現への影響(感覚器,ポスター,「出島」游學-形態通詞の未来展開-,第49回日本組織細胞化学会総会・学術集会)
- PII-16 ヒト乳突蜂巣の正常発育におけるアポトーシスの関与の検討(アポトーシス,ポスター,「出島」游學-形態通詞の未来展開-,第49回日本組織細胞化学会総会・学術集会)
- PII-13 ヒト大腸粘膜のリンパ管の同定、分布の検索 : IgG-gold silver法とエンビジョンキットを用いたDAB法の比較(免疫組織化学(III),ポスター,「出島」游學-形態通詞の未来展開-,第49回日本組織細胞化学会総会・学術集会)
- P-37 イムノブロット法は抗PYY, NPY, およびPP抗体の交差性検定によい手段である
- RNAiについての基礎と応用(E.核酸・タンパクの修飾と可視化および硬組織の組織化学)