Risk of Cerebral Infarction assessed by Fasting Insulin and Fasting Glucose in a Japanese General Population： The Jichi Medical School Cohort Study

概要

論文の詳細を見る
This study was performed to examine the relation between the risk of cerebral infarction and fastinginsulin （FI） stratified by fasting glucose （FG） in a Japanese general population. The subjects were 2,608men and women, examined between 1992 and 1995 as part of the Jichi Medical School Cohort Study.Subjects were divided into nine groups；group1（ G1） with tertile 1（ T1） of FI and T1 of FG, G2 with T2 ofFI and T1 of FG , G3 with T3 of FI and T1 of FG, G4 with T1 of FI and T2 of FG, G5 with T2 of FI and T2 ofFG, G6 with T3 of FI and T2 of FG, G7 with T1 of FI and T3 of FG, G8 with T2 of FI and T3 of FG and G9with T3 of FI and T3 of FG. Cox's proportional hazard model was used to calculate hazard ratios （HRs）and 95％ confidence intervals （CIs） for cerebral infarction. During an average of 11.1 years of follow-up,87 participants developed cerebral infarction. In multivariate-adjusted analysis, HRs of cerebral infarctionwere 3.93（ 95％ CI, 1.13 – 13.72） in G1, 2.30（ 0.51 – 10.34） in G3, 2.19（ 0.58 – 8.19） in G4, 1.18（ 0.26 – 5.31）in G5, 2.96（ 0.81 – 10.88） in G6, 3.48（ 0.97– 12.53） in G7, 2.39（ 0.66 – 8.62） in G8 and 3.73（ 1.09 – 12.84）in G9, using G2 as the reference. The association between FI and risk of cerebral infarction seemed to beU-shaped and this association was seen in each FG level.
自治医科大学の論文