D-aspartate oxidase activity and d-aspartate content of the senescence-accelerated mouse

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Both of senescence-accelerated prone mouse strain (SAM P/1) and senescence-accelerated resistant mouse strain (SAM R/1) are known to lack D-amino acid oxidase activity. In this study we examined D-aspartate oxidase activity in these strains and found its presence in the kidney, liver and brain. The activities in each tissue of the two strains were mostly similar, and they were, more or less, comparable with those of normal ddY and ICR strains. We also examined D-aspartate content and found it to be present in these tissues and blood, in amounts comparable to those reported for other mouse strains. The results are in agreement with our previous observation on a mutant ddY strain (ddY/DAO-) that also lacks D-amino acid oxidase activity, and afford a second example of mouse strains lacking D-amino acid oxidase activity and having intact D-aspartate oxidase activity.
長岡技術科学大学の論文
1999-02-10