パーキンソン振戦の数理的モデル

概要

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A computer simulation of Parkinsonian tremor using a mathematical model is presented, which integrates the traditional two theories; 'peripheral feedback theory' for physiological tremor and 'central oscillator theory' for Pakinsonian tremor. The proposed model includes a basic stretch-reflex loop, which is modulated by the central nervous system through the gamma fibers. Fatigue of intrafusal muscle fibers, which comes from chronic stimulation by the gamma system, is assumed to be the main cause of Parkinsonian tremor. A computer simulation using the model shows that both physiological tremor and Parkinsonian tremor can be caused by varing contractivity of the intrafusal muscle fibers.
長岡技術科学大学の論文