A Versatile Intermediate for the Systematic Synthesis of all Regioisomers of myo-Inositol Phosphates
スポンサーリンク
概要
- 論文の詳細を見る
Inositol phosphate derivatives are usually synthesized by repeated protection-deprotection procedures, necessitating development of an independent synthetic route for each inositol derivative. Herein, a synthetic precursor for all regioisomers of inositol phosphate has been prepared. A cycloadduct obtained by the Diels-Alder reaction of trans-1-methoxy-3-trimethylsilyloxy-1,3-butadiene and methyl vinyl ketone was converted into an inositol derivative by sequential introduction and immediate protection of hydroxyl groups. Thus, the six hydroxyl groups of the obtained inositol derivative are differentiated by different protective groups that are cleavable under independent conditions. This would enable us to prepare all regioisomers of inositol phosphate derivative.
- Georg Thieme Verlagの論文
Georg Thieme Verlag | 論文
- Synthesis of Pinacol Allylic Boronic Esters via Olefin Cross-Metathesis between Pinacol Allylboronate and Terminal or Internal Alkenes
- Palladium-catalyzed intramolecular CH arylation of five-membered N-heterocycles
- [Rh(OH)(cod)]2 (cod = 1,5-Cyclooctadiene): A Highly Efficient Catalyst for 1,4-Hydrosilylation of α,β-Unsaturated Carbonyl Compounds
- A Coupling Reaction of Aryltributyltin with Olefins Mediated by Palladium(II) Acetate
- Inter- and Intramolecular Additions of 1-Alkenylboronic Acids or Esters to Aldehydes and Ketones Catalyzed by Rhodium(I) Complexes in Basic, Aqueous Solutions