Human papillomavirus in lung carcinomas among three Latin American countries
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概要
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The presence of human papillomavirus (HPV) genome in lung carcinomas has been reported worldwide butits frequency varies from country to country. We examinedHPV genome in 36 lung carcinomas, consisting of 14squamous cell carcinomas, 13 adenocarcinomas, and 9 smallcell carcinomas, collected from Colombia, Mexico and Peru.PCR analysis using GP5+/GP6+ primers, combined withSouthern blot hybridization, found the presence of HPVgenome in 1O (28%) of 36 cases. This percentage is similarto the value of 22% reported by Syrjänen, who conducted ameta-analysis of nearly 2500 lung carcinomas examined todate. Genotype analysis revealed that the most predominantgenotype was HPV-16 (7 cases), followed by HPV-18 (2 cases)and HPV-33 (1 case). HPV-16 was more frequently foundamong female than male cases (P=0.008) but was notdetected in any adenocarcinoma cases. On the other hand,HPV-18 and HPV-33 were detected only among male cases.These HPV genotypes were detected only in adenocarcinomas, and all the HPV genotypes detected in thishistological type were HPV-18 or HPV-33. The frequency ofHPV-16 positive cases among all the HPV positive casesdiffered in the sexes (P=0.033) and differed in the threehistological types (P=0.017). The presence of HPV tended tobe more frequent in well-differentiated tumors when squamouscell carcinomas and adenocarcinomas were combined.However, it was not statistically significant(P=0.093).Neither pl6 nor p53 expression in carcinoma cells wasrelated to the proportion of HPV-positive cases. Inconclusion, high-risk HPV DNA was detected in 28% oflung carcinomas. The predisposition of HPV-16 to femalecases and to non-adenomatous carcinomas warrants furtherinvestigation.
- Spandidos Publicationsの論文
- 2006-04-01
Spandidos Publications | 論文
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