Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma
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概要
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Background: Twist is a basic helix-loop-helix (bHLH) transcriptional factor that has beenidentified to play an important role in epithelial-mesenchymal transition (EMT)-mediated metastasisthrough the regulation of E-cadherin expression. However, few authors have examined theexpression of Twist and E-cadherin and their prognostic value in patients with esophagealsquamous cell carcinoma (ESCC). The purpose of this study is to evaluate the clinical significanceof Twist and E-cadherin expression in ESCC.Methods: We immunohistochemically investigated the relationship between their expression andclinicopathological factors including prognosis in surgical specimens of primary tumors in 166patients with ESCC.Results: The expression rate of high Twist was 42.0% and that of preserved E-cadherin was 40.4%.The expression of high Twist and reduced E-cadherin was significantly associated with depth oftumor invasion, lymph node metastasis, distant nodal metastasis, stage and lymphatic invasion, andpoor prognosis. High Twist expression significantly correlated with reduced E-cadherin expression.In the preserved E-cadherin group, the 5-year survival rate was better for patients who were lowfor Twist expression than for those who were high for Twist expression. Multivariate analysisindicated that the combination of low Twist and preserved E-cadherin expression was anindependent prognostic factor along with tumor depth, distant nodal metastasis and E-cadherinexpression.Conclusions: Evaluation of Twist and E-cadherin expressions should be useful for determiningtumor properties, including prognosis, in patients with ESCC.
- BioMed Centralの論文
- 2009-12-21
BioMed Central | 論文
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