Prognostic impact of CD168 expression in gastric cancer
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Background: Interactions of stromal hyaluronic acid (HA) with its binding protein RHAMM (receptor for HAmediatedmotility) (CD168) have been reported to affect tumor extension and the migration of crucial moleculesto promote tumor progression and metastases. Cancerous CD168 expression is correlated with aggressivebiological features in several cancers. However, the clinical implications of CD168 positivity in gastric cancer haveremained unclear.Methods: We examined the CD168 expression of 196 consecutive gastric cancer patients byimmunohistochemistry. According to CD168 positivity, the 196 gastric cancer patients were divided into twogroups (57 CD168-positive and 139 CD168-negative patients). The correlation between CD168 expression andclinicopathological factors (age, sex, histology, tumor depth, lymph node status, and vessel invasion) was evaluatedaccording to the Japanese Classification of Gastric Carcinoma.Results: Cancerous CD168 expression was detectable in 57 of the 196 tumors (29%). CD168 positivity wassignificantly correlated with the depth of invasion, nodal involvement, and vessel invasion (p < 0.01). Survivalanalysis of the 196 gastric cancer patients showed that the CD168-positive group had a significantly highermortality than the CD168-negative group (p < 0.01). In terms of a correlation with CD168 positivity at separateclinical stages, a significance difference was only found in stages II and III. Multivariate analysis revealed that CD168expression was a significant independent prognostic marker (p = 0.013) after depth of invasion (p < 0.005) andnodal involvement (p < 0.01).Conclusion: Our results suggest that cancerous CD168 positivity is strongly related to the invasion and metastasisof gastric cancer tumors. These results suggest that cancerous CD168 expression can be used as a prognosticmarker of gastric cancer owing to its interactions with stromal hyaluronic acid.
- BioMed Centralの論文
- 2011-03-24
BioMed Central | 論文
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