Analysis of T-helper type 1 and 2 cells and T-cytotoxic type 1 and 2 cells of sentinel lymph nodes in breast cancer
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The immune suppression of sentinel lymph node(SN) is directly influenced by primary tumors. It has beenreported that the T-helper type 1 (Th1) to T-helper type 2(Th2) ratio or T-cytotoxic type 1 (Tc1) to T-cytotoxic type 2(Tc2) ratio of lymph node lymphocytes could be used toevaluate direct immunological circumstances. We attemptedto evaluate the Th1 to Th2 cell and Tc1 to Tc2 cell balance inSN and non-SN and to clarify the immunological status ofsentinel nodes in breast cancer. To evaluate this balance, SNand non-SN were identified by radioguided methods andlymph node lymphocytes were collected, and prepared forflow cytometry. The Th1 to Th2 and Tc1 to Tc2 ratio werecalculated by 3-color flow cytometry. The ratio of SN andnon-SN was compared. The results demonstrated that SN wasdetected in 24 out of 24 patients (100%). As regards thecorrelation between SN and non-SN in the same patients, theTh1 to Th2 ratio in SN was significantly lower than that innon-SN for all patients (p<0.05). Among clinicopathologicalfactors, a larger tumor diameter, histology and nodalinvolvement affected the decreased Th1 to Th2 ratio in SNsignificantly (p<0.05). We reached the conclusion that theincreasing immunosuppressive conditions derived from thetumor may deteriorate the Th1 to Th2 ratio of SN in an earlierstage as compared with non-SN. According to the tumorextension and nodal involvement, the Th1 to Th2 ratio in SNwas significantly suppressed. The current result supports thatmainly helper T-cell paralysis occurred first in SN and thisseems to be a favorable condition in forming lymph nodemetastases in SN. Moreover, the immunologic interactionbetween the primary site and regional lymph nodes may serveas useful criteria for identifying sentinel nodes.
- Spandidos Publicationsの論文
- 2008-03-01
Spandidos Publications | 論文
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