Expression of Immunoreactivities for Manganese and Copper/Zinc Superoxide Dismutases(Mn-and Cu/Zn-SODs)During Development of the Rat Submandibular Gland
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Manganase- and copper-zinc superoxide dismutases (Mn- and Cu/Zn-SODs) are representative enzymes for scavenging superoxide radicals, which are considered to cause aging and cell damage. Our recent study has demonstrated the localization of Mn-and Cu/Zn-SOD proteins as well as the expression of Mn-and Cu/Zn-SOD mRNAs in all types of duct cells-and not in acinar cells- in the submandibular gland of adult rats. However, the expression of these two enzymes remains unclear in rat developing submandibular gland. Thus, the present study examined the expression of Mn- and Cu/Zn-SODs in the submandibular gland of rats aged from embryonic 18 days to postnatal 8 weeks by an immunohistochemical technique using specific antisera. The deparaffinized sections were processed for the avidin-biotin complex method. On the prenatal 18th day, a small number of epithelial duct cells and cells in acini exhibited Cu/Zn-SOD-immunoreactivity, but they did not show any immunoreactions for Mn-SODs. From postnatal 1day to 1 week, Mn- and Cu/Zn-SOD-immunoreactivities were found in both the duct cells and the cells in acini. This drastic change in the expression of Mn- and Cu/Zn-SOD-immunoreactivities between prenatal and postnatal periods was believed to relate to the commencement of pulmonary respiration due to oxygen exposure. After 2 weeks, however, the cells in the acini lost Mn- and Cu/Zn-SOD-immunoreactions, though the duct cells retained them, suggesting that the duct cells in the mature submandibular gland exhibit greater resistance against oxidative stress than do the acinar cells.
- 新潟歯学会の論文
- 2002-12-00
新潟歯学会 | 論文
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