Voxel-based structural magnetic resonance imaging (MRI) study of patients with early onset schizophrenia
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Background: Investigation into the whole brain morphology of early onset schizophrenia (EOS)to date has been sparse. We studied the regional brain volumes in EOS patients, and thecorrelations between regional volume measures and symptom severity.Methods: A total of 18 EOS patients (onset under 16 years) and 18 controls matched for age,gender, parental socioeconomic status, and height were examined. Voxel-based morphometricanalysis using the Brain Analysis Morphological Mapping (BAMM) software package was employedto explore alterations of the regional grey (GM) and white matter (WM) volumes in EOS patients.Symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS).Results: EOS patients had significantly reduced GM volume in the left parahippocampal, inferiorfrontal, and superior temporal gyri, compared with the controls. They also had less WM volume inthe left posterior limb of the internal capsule and the left inferior longitudinal fasciculus. Thepositive symptom score of PANSS (higher values corresponding to more severe symptoms) wasnegatively related to GM volume in the bilateral posterior cingulate gyrus. The negative symptomscore was positively correlated with GM volume in the right thalamus. As for the association withWM volume, the positive symptom score of PANSS was positively related to cerebellar WM(vermis region), and negatively correlated with WM in the brain stem (pons) and in the bilateralcerebellum (hemisphere region).Conclusion: Our findings of regional volume alterations of GM and WM in EOS patients coincidewith those of previous studies of adult onset schizophrenia patients. However, in brain regions that had no overall structural differences between EOS patients and controls (that is, the bilateralposterior cingulate gyrus, the right thalamus, the cerebellum, and the pons), within-subject analysisof EOS patients alone revealed that there were significant associations of the volume in these areasand the symptom severity. These findings suggest that at an early stage of the illness, especially forthose with onset before brain maturation, a wide range of disturbed neural circuits, including thesebrain regions that show no apparent morphological changes, may contribute to the formation ofthe symptomatology.
- BioMed Centralの論文
- 2008-12-22
BioMed Central | 論文
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