Intrathecal cocaine delivery enables long-access self-administration with binge-like behavior in mice

概要

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Rationale: Long-access intravenous drug self-administration shows diurnal alterationsin drug intake, with escalation and binge patterns, in rats. A similar long-access modelin mice would allow the use of genetically modified animals to better understand themolecular mechanisms underlying drug addiction and relapse. However, attempts totransfer this model to mice have been less successful, mainly because of technicaldifficulties with long-term maintenance of the indwelling catheter implanted into smallveins.Objectives: We devised an intrathecal probe implanted in the supracerebellar cistern asan alternative for intravenous drug administration to address this challenge and allowcontinuous, chronic drug self-administration in mice.Results: We found that mice readily self-administered intrathecal infusions of cocaine asa drug reward, and, under daily 24-h access conditions, animals exhibited a binge-likebehavior comparable to rats.Conclusions: This innovation enables a full analysis of long-access drugself-administration behavior in mice not possible with intravenous administration.
Springerの論文
2011-01-00