Synthesis of a new type of artificial nucleic acid derived from optically active serine
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概要
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This paper describes the synthesis of a new type of nucleic acid analog derived from L-serine with ester linkages. The monomer unit bearing thymine base was synthesized from L-serine ethyl ester by a three-step reaction in good yield without racemization. 3-Nitro-l,2,4-triazol-l-yl-tris(pyrrolidin-l-yl)phosphonium hexafluorophosphate (PyNTP) was found to be highly effective for the rapid ester bond formation without racemization. 2-Phenyl-2-(trimethylsilyl)ethyl group was successfully employed as a carboxyl protecting group in solution-phase synthesis.
- Oxford University Pressの論文
- 1905-06-23
Oxford University Press | 論文
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