睡眠と生体リズム
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概要
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Circadian rhythm is an endogenous rhythm controlled by a master oscillator (biologicalclock) in the supra-chiasmatic nucleus (SCN), affecting on the almost all physiologicalfunctions including sleep/wake regulation. Recently the biological clock has been shown tofunction at the molecular level, and several circadian-related genes have been identified,such as the Clock, Per 1-3, Bmal 1 or Cry 1, 2.We observed the sleep/wake rhythm in cry 1, 2 double knockout mice and clock mutantmice. Both strains have lost the circadian oscillation in the expression of circadian-relatedgenes. Cry 1, 2 double knockout mice show the entrained sleep/wake rhythm to ordinarylight-dark (LD) cycle, although they show completely flattened rhythm under the constantdark (DD) condition. On the other hand, clock mutant mice show the persistent circadiansleep/wake rhythm under even DD conditions. Although the expression of circadianrelatedgenes do not oscillate, the clock mutant mice have potent circadian rhythm in bodycore temperature, behavior, sleep/wake and cortisol etc. The clock mutant mice have alonger (27 hrs) period of free-running rhythm under DD condition, and the phase of sleep/wake rhythm is delayed for about two hours comparing to the wild-type under LD condition.The important role of the circadian-related genes in the sleep/wake regulation has beenindicated. The functional impairment of the circadian-related genes may be involved in thesleep disorders, such as insomnia or hypersomnia.
- 徳島医学会の論文
- 2004-05-25
徳島医学会 | 論文
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