Analysis of anatomical and functional determinants of obstructive sleep apnea.
スポンサーリンク
概要
- 論文の詳細を見る
[Purpose] Craniofacial abnormalities have an important role in the occurrence of obstructive sleep apnea (OSA) and may be particularly significant in Asian patients, although obesity and functional abnormalities such as reduced lung volume and increased airway resistance also may be important. We conducted simultaneous analyses of their interrelationships to evaluate the relative contributions of obesity, craniofacial structure, pulmonary function, and airway resistance to the severity of Japanese OSA because there are little data in this area. [Methods] A cross-sectional observational study was performed on 134 consecutive Japanese male patients. A sleep study, lateral cephalometry, pulmonary function tests, and impulse oscillometry (IOS) were performed on all patients. [Results] Age, body mass index (BMI), position of the hyoid bone, and proximal airway resistance on IOS (R20) were significantly related to the apnea/hypopnea index (AHI) (p < 0.05) in multiple regression analysis. Subgroup analysis showed that, for moderate-to-severe OSA (AHI ≥ 15 events/h), neck circumference and R20 were predominantly related to AHI, whereas for non-to-mild OSA (AHI < 15 events/h), age and expiratory reserve volume were the predominant determinants. In obese subjects (BMI ≥ 25 kg/m2), alveolar–arterial oxygen tension difference, position of the hyoid bone, and R20 were significantly associated with AHI, whereas age alone was a significant factor in nonobese subjects (BMI < 25 kg/m2). [Conclusions] Aside from age and obesity, anatomical and functional abnormalities are significantly related to the severity of Japanese OSA. Predominant determinants of AHI differed depending on the severity of OSA or the magnitude of obesity.
論文 | ランダム
- 核・放射線による分析--生物学・医学・薬学・農学・理工学への応用-6-中性子を利用した分析
- 352 厚肉鋼材のマクロ偏析部の変態特性について : 厚肉鋼材の水素性超音波欠陥防止に関する研究 2(高張力鋼板・低温用鋼, 性質, 日本鉄鋼協会 第 98 回(秋季)講演大会)
- 351 厚肉鋼材のマクロ偏析部の組成について : 厚肉鋼材の水素性超音波欠陥防止に関する研究 1(高張力鋼板・低温用鋼, 性質, 日本鉄鋼協会 第 98 回(秋季)講演大会)
- 469 圧力容器用鋼およびタービンローター材の使用温度における焼もどし脆性(制御圧延・低温用鋼 (II)・圧力容器用鋼, 性質, 日本鉄鋼協会 第 97 回(春季)講演大会)
- 274 応力除去焼なまし脆化にともなう破面構造の変化について(高張力鋼板・鍛鋼・厚板・制御圧延, 性質・分析, 日本鉄鋼協会第 93 回(春季)講演大会)