Analysis of anatomical and functional determinants of obstructive sleep apnea.
スポンサーリンク
概要
- 論文の詳細を見る
[Purpose] Craniofacial abnormalities have an important role in the occurrence of obstructive sleep apnea (OSA) and may be particularly significant in Asian patients, although obesity and functional abnormalities such as reduced lung volume and increased airway resistance also may be important. We conducted simultaneous analyses of their interrelationships to evaluate the relative contributions of obesity, craniofacial structure, pulmonary function, and airway resistance to the severity of Japanese OSA because there are little data in this area. [Methods] A cross-sectional observational study was performed on 134 consecutive Japanese male patients. A sleep study, lateral cephalometry, pulmonary function tests, and impulse oscillometry (IOS) were performed on all patients. [Results] Age, body mass index (BMI), position of the hyoid bone, and proximal airway resistance on IOS (R20) were significantly related to the apnea/hypopnea index (AHI) (p < 0.05) in multiple regression analysis. Subgroup analysis showed that, for moderate-to-severe OSA (AHI ≥ 15 events/h), neck circumference and R20 were predominantly related to AHI, whereas for non-to-mild OSA (AHI < 15 events/h), age and expiratory reserve volume were the predominant determinants. In obese subjects (BMI ≥ 25 kg/m2), alveolar–arterial oxygen tension difference, position of the hyoid bone, and R20 were significantly associated with AHI, whereas age alone was a significant factor in nonobese subjects (BMI < 25 kg/m2). [Conclusions] Aside from age and obesity, anatomical and functional abnormalities are significantly related to the severity of Japanese OSA. Predominant determinants of AHI differed depending on the severity of OSA or the magnitude of obesity.
論文 | ランダム
- 示II-352 急性胆嚢炎に対する術前PTGBDの有用性(第52回日本消化器外科学会総会)
- 窓と遮音性 (特集 建築外装と窓の設計) -- (性能)
- 139 胆嚢総胆管結石症の治療方針とその成績
- 防音 (集合住宅のリフォ-ム技術)
- 561 膵体部良性病変に対する膵分節切除・尾側膵空腸吻合の有用性(第38回日本消化器外科学会総会)