Effectiveness of Indonesian Honey on the Acceleration of Cutaneous Wound Healing: An Experimental Study in Mice

概要

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The purpose to investigate the effectiveness of Indonesian honey in wound healing incomparison with Tegaderm hydrocolloid dressing and Manuka honey. Three groups of malemice were treated to produce two circular full-thickness skin wounds on the dorsum. Theywere then randomly allocated to receive daily Indonesian honey, Manuka honey orhydrocolloid as a control for treatment application. Macroscopic findings were observed fromday 0 to 14 after wounding. Microscopic findings on days 3, 7, 11 and 14 after woundingwere obtained. The ratios of wound areas for honey groups on day 3 were smaller than thoseof the control group. Wound areas of honey groups gradually decreased to almost the samewound area as the control group on day 14, while the wound area of the control group peakedon day 5 and rapidly decreased until day 14. On day 3, myofibroblasts and new bloodcapillaries in wound tissue of honey groups were observed, but not in the control group. Afterday 7, microscopic findings were almost the same among all groups. These results indicatethat Indonesian honey is almost as effective for wound healing as Manuka honey andTegaderm hydrocolloid dressing.