Development of programmable small DNA-binding molecules with epigenetic activity for induction of core pluripotency genes.
スポンサーリンク
概要
- 論文の詳細を見る
Epigenetic modifications that govern the gene expression are often overlooked with the design of artificial genetic switches. N-Methylpyrrole-N-methylimidazole (PI) hairpin polyamides are programmable small DNA binding molecules that have been studied in the context of gene regulation. Recently, we synthesized a library of compounds by conjugating PI polyamides with SAHA, a chromatin-modifier. Among these novel compounds, PI polyamide-SAHA conjugate 1 was shown to epigenetically activate pluripotency genes in mouse embryonic fibroblasts. Here, we report the synthesis of the derivatives of conjugate 1 and demonstrate that these epigenetically active molecules could be developed to improve the induction of pluripotency factors.
- 2012-04-15
論文 | ランダム
- マイクロリング光回路を用いた波長選択スイッチ (特集 光ネットワーク時代の光技術)
- ARROW型光導波路と3次元光集積回路 (特集 光マイクロデバイス)
- 331 イネシストセンチュウの陸稲に対する被害(昭和39年度日本農学会大会分科会)
- 260 食用トウモロコシに対するアワノメイガの加害と防除時期(昭和39年度日本農学会大会分科会)
- 247 栃木県におけるマラソン抵抗性ツマグロヨコバイ(昭和39年度日本農学会大会分科会)