Hippocampal CA3 and CA2 have distinct bilateral innervation patterns to CA1 in rodents
スポンサーリンク
概要
- 論文の詳細を見る
Ipsi-and contralateral hippocampal CA3–CA1 and CA2–CA1 projections were investigated in adult male Long–Evans rats by retrograde tracing. Injection of the retrograde tracer cholera toxin subunit B in the strata oriens and radiatum of dorsal CA1 resulted in labeling of predominantly pyramidal cells in ipsilateral and contralateral CA3 and CA2. The contralateral and ipsilateral anterior–posterior extents of CA3 innervation to CA1 were similar. Fifteen to twenty per cent of the hippocampus proper cells that give rise to CA1 stratum oriens innervation were CA2 pyramidal cells, whereas CA2 cells were a mere 3% for CA1 stratum radiatum innervation. The preferred projection of CA2 pyramidal cells to the CA1 stratum oriens was also manifested in transgenic mice that express GFP under the control of the CACNG5 promoter, in which CA2 cells express high amounts of GFP. The ratios of ipsilateral to contralateral projections were compared. For the CA3–CA1 connection, we found that dorsal CA1 stratum radiatum received more ipsilateral projections whereas CA1 stratum oriens received more contralateral innervation. Interestingly, ipsilateral connections dominated for both CA2–CA1 stratum oriens and CA2–CA1 stratum radiatum. These results demonstrate that the primary intrahippocampal target of CA2 pyramidal cells is the ipsilateral CA1 stratum oriens, in contrast to CA3 cells which project more diversely to bilateral CA1 regions. Such innervation patterns may suggest differential dendritic information processing in apical and basal dendrites of CA1 pyramidal cells.
論文 | ランダム
- 免疫系のしくみ (生涯教育シリーズ(67)わかりやすい免疫疾患) -- (カラー口絵 眼でみる免疫疾患のしくみ)
- A Novel 3.5 kDa Protein Component of Cyanobacterial Photosystem I Complexes : MEMBRANES AND BIOENERGETICS
- 魚類の栄養素としてのタウリン機能 (特集 タウリン解禁!--養魚飼料の新たな展開)
- 情報処理教育がどう生かされているか
- 「電子計算機一般」におけるコボル言語の指導法--副教材としての機械操作法