HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines.
スポンサーリンク
概要
- 論文の詳細を見る
Adult T-cell leukemia (ATL) patients and human T-cell leukemia virus-1 (HTLV-1) infected individuals succumb to opportunistic infections. Cell mediated immunity is impaired, yet the mechanism of this impairment has remained elusive. The HTLV-1 basic leucine zipper factor (HBZ) gene is encoded in the minus strand of the viral DNA and is constitutively expressed in infected cells and ATL cells. To test the hypothesis that HBZ contributes to HTLV-1-associated immunodeficiency, we challenged transgenic mice that express the HBZ gene in CD4 T cells (HBZ-Tg mice) with herpes simplex virus type 2 or Listeria monocytogenes, and evaluated cellular immunity to these pathogens. HBZ-Tg mice were more vulnerable to both infections than non-Tg mice. The acquired immune response phase was specifically suppressed, indicating that cellular immunity was impaired in HBZ-Tg mice. In particular, production of IFN-γ by CD4 T cells was suppressed in HBZ-Tg mice. HBZ suppressed transcription from the IFN-γ gene promoter in a CD4 T cell-intrinsic manner by inhibiting nuclear factor of activated T cells and the activator protein 1 signaling pathway. This study shows that HBZ inhibits CD4 T-cell responses by directly interfering with the host cell-signaling pathway, resulting in impaired cell-mediated immunity in vivo.
- 2012-01-12
論文 | ランダム
- 40) ピルジカイニド(サンリズム)投与中Tors ade de pointesを発症した巨大冠動脈瘤の一症例(日本循環器学会 第66回中国地方会)
- 127)虚血性心疾患患者における内臓脂肪量、血清多価不飽和脂肪酸と冠動脈病変の検討(日本循環器学会第65回中国四国地方会)
- 幼児の目撃記憶の発達--顔の再認成績に及ぼす言語供述の影響
- 71)抗精神病薬によりTorsade de pointesを発症したと考えられた3症例(日本循環器学会第65回中国四国地方会)
- 47)高血圧合併虚血性心疾患における左室心筋重量と内臓脂肪量の関連性について(日本循環器学会第65回中国四国地方会)