Selective upregulation of p66-Shc gene expression in the liver and brain of aged rats.
スポンサーリンク
概要
- 論文の詳細を見る
The phosphotyrosine signaling followed by various receptor activations conforms a unique signaling platform during metazoan evolution, and is crucial for animal development, maturation, and aging. Shc is the most versatile bipartite phosphotyrosine signal adaptor harboring phosphotrosine-biding (PTB) and Src-homology2 (SH2) domains. Among the Shc adaptor family members, p66-Shc is of potential interest in aging studies, since its deletion in mice resulted in a longer lifespan and/or higher quality of life in later stages of life. However, a few studies have examined the gene expression profiles of p66-Shc in aging tissues. Here, we quantified the expression levels of transcripts of Shc-related isoforms in the liver and brain of young adult, middle-aged, and aged rats, and found that p66-Shc gene expression is specifically up-regulated in the aged liver and brain. In the aged liver tissue, p66-Shc expression was also evident at the protein level, and accumulated in the soluble fraction of the aged tissue. These results indicate that p66-Shc is not only related to animal longevity but also affected during aging, and thus the repression of p66-Shc could become a potential target for an anti-aging strategy.
- 2011-11-28
論文 | ランダム
- 2009年賃金構造基本統計調査による標準労働者の年収試算--所定内給与の12倍に年間賞与を加えた年齢別の実在者データ(労務行政研究所)
- 年収--定期給与に賞与を加えたモデル年収,役職者の平均年収ほか (2010年度モデル賃金・年収調査--年収は大学卒モデル35歳で578万円,役職別では部長が973万円と減少傾向(労務行政研究所))
- 河村たかし・名古屋市長が給与半減にこだわり続ける理由とは 「役人天国」市長たちが挑む厚遇改革の一部始終 (「業界・会社・役職・学歴別」全データ公開! 「給料」崩壊)
- 内分泌の老化とホルモン補充療法 (特集 アンチエイジングを科学する)
- 女性ホルモンと高血圧 (〔2002年〕8月第5土曜特集 高血圧のすべて) -- (高血圧の臨床)