Effects of fermented brown rice on the intestinal environments in healthy adult

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Purpose : The aim of this study is to investigate the prebiotic effects of brownrice fermented by Aspergillus oryzae (FBRA) on the intestinal environment in vitro andin healthy adults. Methods : Fresh fecal slurries from six healthy adults were incubatedwith FBRA to confirm prebiotic potentials of FBRA. Another thirty-six healthy adultswere randomly allocated to 2 groups for the clinical study. Subjects consumed 21.0 g/dayof either FBRA or control food for 2 weeks, followed by a 12-week intermission and then2-week ingestion vice versa. Main outcome measures were bifidobacterial numbers andorganic acid concentration in feces. Sub outcome measures were fecal microbiota, fecalenvironments and bowel function. Results : Incubation of fecal slurries with FBRA invitro resulted in increased organic acids with individual-specific patterns. Bifidobacterialnumbers were increased during incubation. In the clinical study, all participantssafely completed this study. FBRA had little effect on fecal number of bifidobacteria, concentrationsof organic acids or putrefactive metabolites, fecal pH, or fecal microbiota.Conclusion : FBRA has the potentials as a prebiotic, however, we could not detect itseffects on the intestinal environment in vivo. The results in a clinical study indicated thatFBRA could be safely used for healthy adults.