Mineral to matrix ratio determines biomaterial and biomechanical properties of rat femur : application of Fourier transform infrared spectroscopy
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We studied the changes of biomaterial and biomechanical properties of the ratfemur during development. Thirty male Wistar rats were allocated to 6 groups : aged 6weeks (n=5), 9 weeks (n=5), 12 weeks (n=5), 15 weeks (n=5), 24 weeks (n=5), and 36 weeks(n=5). The mineral to matrix ratio (M/M ratio) of rat femur by Fourier transform infraredspectroscopy was 0.97 0.10 at the age of 6 weeks, and reached the maximum of 1.520.17 at the age of 36 weeks. Total bone mineral density (BMD) by peripheral quantitativecomputed tomography of the femoral shaft aged 6 weeks was 479.1 58.7 mg/cm3, andreached the maximum of 1022.2 42.3 mg/cm3 at the age of 36 weeks. The ultimate load tofailure of the femur of the rat aged 6 weeks by the three-point bending test was 29.6 6.1 N.At the age of 36 weeks, the ultimate load to failure of the rat femur increased to the maximumof 283.5 14.7 N. The results showed that the M/M ratio increased with developmentas total BMD and bone strength increased. The results suggest that the M/M ratio is oneof the determinants of the biomaterial and biomechanical properties of bone.
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