Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer.
スポンサーリンク
概要
- 論文の詳細を見る
We have developed a novel vector constructed with pDNA, polyethylenimine (PEI), and mucin 1 (MUC1) aptamer for tumor-targeted gene delivery. The MUC1 aptamer and non-specific aptamer were employed to coat the pDNA/PEI complexes electrostatically and stable nanoparticles were formed. The addition of a non-specific aptamer to the pDNA/PEI complex decreased gene expression in the human lung cancer cell line, A549 cells expressing MUC1 regularly. At the same time, the pDNA/PEI/MUC1 aptamer complex showed higher gene expression than pDNA/PEI/non-specific aptamer complex. Furthermore, the pDNA/PEI/MUC1 aptamer complex showed markedly high gene expression in tumor-bearing mice; thus, pDNA/PEI/MUC1 aptamer complexes are useful as a tumor-targeted gene delivery system with high transfection efficiency.
- 2011-10-01
論文 | ランダム
- 木構造クラスタを用いたアドホックネットワークルーティングプロトコルの評価(トラヒック,一般)
- Fused Pyrimidines. IV. The Reaction of 4-Alkylthio-2-chloroquinazolines with Alkylamines in Dimethylformamide
- ピリミジンから1,3,5-トリアゼピンへの新規環拡大反応
- 6-Azido-1,3-dimethyluracilとAcyl Halideの光反応による5-Acylamino-6-chloro-1,3-dimethyluracil類の新合成法
- 国史跡斎宮跡調査の最新成果から : 史跡東部の区画造営プランをめぐって